Chemistry:List of investigational antipsychotics
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This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Receptor modulators
Monoamine receptor modulators
- Brilaroxazine (RP5063; oxaripiprazole) – atypical antipsychotic (D2/3/4 and 5-HT1A partial agonist and 5-HT2A/2B/7 antagonist)[1]
- FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[2]
- Masupirdine (SUVN-502) – 5-HT6 receptor antagonist[3]
- N-methyl amisulpride (LB-102) – D2,3, 5-HT7, receptor antagonists (methylated version of amisulpride)[4]
- Ralmitaront (RG-7906, RO-6889450) – TAAR1 agonist[5]
- Ulotaront (SEP-856, SEP-363856) – 5-HT1A receptor and TAAR1 agonist[6]
- Usmarapride (SUVN-D4010) – 5-HT4 receptor partial agonist[7]
Glutamate receptor modulators
Acetylcholine receptor modulators
- Emraclidine (CVL-231) – M4 muscarinic acetylcholine receptor positive allosteric modulator.[9]
- KarXT (xanomeline/trospium) – combined M1 and M4 muscarinic acetylcholine receptor agonist and peripherally-selective muscarinic acetylcholine receptor antagonist.[10]
- ML-007 – M1 and M4 muscarinic acetylcholine receptor agonist.[11]
- NBI-1117568 (HTL 0016878) – M4 muscarinic acetylcholine receptor agonist.[12]
Cannabinoid receptor modulators
- Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions[13][14]
Other/mixed receptor modulators
- CVN766 – Orexin receptor type 1 antagonist[15]
- Deudextromethorphan (d-DM; AVP-786, CTP-786) – σ1 receptor agonist, serotonin–norepinephrine reuptake inhibitor, uncompetitive NMDA receptor antagonist, muscarinic acetylcholine receptor agonist, other actions[16][17]
- Roluperidone (CYR-101, MIN-101, MT-210) – 5-HT2A and σ2 receptor antagonist[18]
- TAK-041 (NBI 1065846) – GPR139 receptor agonist[19]
Enzyme inhibitors
- Luvadaxistat (NBI 1065844, TAK-831) – D-amino acid oxidase inhibitor.[20]
- MK-8189 – phosphodiesterase 10A inhibitor.[21]
- Osoresnontrine (BI-409306, SUB-166499) – phosphodiesterase 9A inhibitor[22]
- Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D-amino acid oxidase inhibitor[23]
Ion channel modulators
- Evenamide (NW-3509; NW-3509A) – Nav1.3, Nav1.7, and Nav1.8 voltage-gated sodium channel blocker[24]
Others
- TS-134 (TS-1341) – undefined mechanism of action[25]
- Kratom – Has shown antipsychotic-like effects on par with haloperidol[26][27]
See also
References
- ↑ "Brilaroxazine - Reviva Biopharmaceuticals - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800035778. Retrieved 14 February 2020.
- ↑ "FKF 02SC - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800029441. Retrieved 14 February 2020.
- ↑ "Masupirdine - Suven Life Sciences - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800028819. Retrieved 14 February 2020.
- ↑ "N-methyl amisulpride - LB pharmaceuticals - AdisInsight". https://adisinsight.springer.com/drugs/800056770.
- ↑ "Ralmitaront - AdisInsight". Springer. https://adisinsight.springer.com/drugs/800044887. Retrieved 10 July 2021.
- ↑ "SEP 363856 - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800036955. Retrieved 14 February 2020.
- ↑ "SUVN D4010 - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800043407. Retrieved 14 February 2020.
- ↑ "Pomaglumetad methionil - Denovo Biopharma/Eli Lilly and Company - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800026989. Retrieved 14 February 2020.
- ↑ "Emraclidine - Cerevel Therapeutics - AdisInsight". https://adisinsight.springer.com/drugs/800056372.
- ↑ "APN 1125 - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800041907. Retrieved 14 February 2020.
- ↑ "ML 007 - AdisInsight". https://adisinsight.springer.com/drugs/800062983.
- ↑ "HTL 0016878 - AdisInsight". https://adisinsight.springer.com/drugs/800050085.
- ↑ "Cannabidiol - GW Pharmaceuticals - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800025601. Retrieved 14 February 2020.
- ↑ "Cannabidiol - Echo Pharmaceuticals - AdisInsight". http://adisinsight.springer.com/drugs/800043019. Retrieved 14 February 2020.
- ↑ "CVN 766 - AdisInsight". https://adisinsight.springer.com/drugs/800066143.
- ↑ "Deudextromethorphan - Avanir Pharmaceuticals - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800035704. Retrieved 14 February 2020.
- ↑ Nguyen, Linda; Thomas, Kelan L.; Lucke-Wold, Brandon P.; Cavendish, John Z.; Crowe, Molly S.; Matsumoto, Rae R. (March 2016). "Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders". Pharmacology & Therapeutics 159: 1–22. doi:10.1016/j.pharmthera.2016.01.016. ISSN 1879-016X. PMID 26826604. https://pubmed.ncbi.nlm.nih.gov/26826604.
- ↑ "Roluperidone - Minerva Neurosciences - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800029911. Retrieved 14 February 2020.
- ↑ "TAK 041 - AdisInsight". https://adisinsight.springer.com/drugs/800045191.
- ↑ "Luvadaxistat - Takeda - AdisInsight". https://adisinsight.springer.com/drugs/800043389.
- ↑ "MK 8189 - AdisInsight". https://adisinsight.springer.com/drugs/800040914.
- ↑ "BI 409306 - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800034095. Retrieved 14 February 2020.
- ↑ "Sodium benzoate - SyneuRx - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800041499. Retrieved 14 February 2020.
- ↑ "Evenamide - Newron Pharmaceuticals - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800026870. Retrieved 14 February 2020.
- ↑ "TS 134 - AdisInsight". Springer. http://adisinsight.springer.com/drugs/800043349. Retrieved 14 February 2020.
- ↑ Vijeepallam, K.; Pandy, V.; Kunasegaran, T.; Murugan, D. D.; Naidu, M. (2016). "Mitragyna speciosa Leaf Extract Exhibits Antipsychotic-Like Effect with the Potential to Alleviate Positive and Negative Symptoms of Psychosis in Mice". Frontiers in Pharmacology 7: 464. doi:10.3389/fphar.2016.00464. PMID 27999544.
- ↑ Johnson, L. E.; Balyan, L.; Magdalany, A.; Saeed, F.; Salinas, R.; Wallace, S.; Veltri, C. A.; Swogger, M. T. et al. (2020). "The Potential for Kratom as an Antidepressant and Antipsychotic". The Yale Journal of Biology and Medicine 93 (2): 283–289. PMID 32607089.
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