Chemistry:Isobavachalcone
From HandWiki
Isobavachalcone is a natural product from the prenylated chalconoid family.[1][2][3]
It can be isolated from numerous medicinal plant species including Psoralea corylifolia, Fructus psoraleae, and Angelica keiskei.[2][3] It has antiiflammatory, antiviral and anti-cancer properties in vitro and plants containing isobavachalcone are used in Chinese herbal medicine for the treatment of osteoporosis and other aging-related diseases.[4][5][6][7]
See also
- Licoflavone C
- Xanthohumol
References
- ↑ "Pharmacological review of isobavachalcone, a naturally occurring chalcone". Pharmacological Research 165. March 2021. doi:10.1016/j.phrs.2021.105483. PMID 33577976.
- ↑ 2.0 2.1 "Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis". Natural Product Reports 38 (12): 2236–2260. December 2021. doi:10.1039/d0np00083c. PMID 33972962.
- ↑ 3.0 3.1 "Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms". Phytotherapy Research 36 (8): 3120–3142. August 2022. doi:10.1002/ptr.7520. PMID 35684981.
- ↑ "Isobavachalcone: an overview". Chinese Journal of Integrative Medicine 18 (7): 543–547. July 2012. doi:10.1007/s11655-012-1142-7. PMID 22772918.
- ↑ "Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases". Oxidative Medicine and Cellular Longevity 2020. 2020. doi:10.1155/2020/2128513. PMID 32655760.
- ↑ "Flavonoids: A complementary approach to conventional therapy of COVID-19?". Phytochemistry Reviews 20 (4): 773–795. 2021. doi:10.1007/s11101-020-09720-6. PMID 32982616. Bibcode: 2021PChRv..20..773S.
- ↑ "Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells". Bioscience, Biotechnology, and Biochemistry 87 (9): 960–971. August 2023. doi:10.1093/bbb/zbad075. PMID 37291698.
Further reading
- "Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway". Journal of Food Biochemistry 44 (9). September 2020. doi:10.1111/jfbc.13405. PMID 32710574.
- "Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells". Bioscience, Biotechnology, and Biochemistry 87 (9): 960–971. August 2023. doi:10.1093/bbb/zbad075. PMID 37291698.
- "Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo". Phytotherapy Research 38 (4): 1815–1829. April 2024. doi:10.1002/ptr.8143. PMID 38349045.
- "Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice". Frontiers in Pharmacology 16. 2025. doi:10.3389/fphar.2025.1525364. PMID 40183098.
- "Isobavachalcone inhibits α-synuclein fibrillogenesis and its Parkinson's disease variants, disassembles the mature fibrils and alleviates cellular toxicity". International Journal of Biological Macromolecules 322 (Pt 1). September 2025. doi:10.1016/j.ijbiomac.2025.146541. PMID 40763859.
- "Isobavachalcone reduces blood glucose and promotes muscle development via dipeptidyl peptidase-4 inhibition". International Journal of Biological Macromolecules 339 (Pt 1). December 2025. doi:10.1016/j.ijbiomac.2025.149858. PMID 41443458.
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