Chemistry:Isometamidium chloride
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Short description: Chemical compound
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| Formula | C28H26ClN7 |
| Molar mass | 496.02 g·mol−1 |
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Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine.[1][2]
It consists of a single ethidium bromide like subunit linked to a fragment of the diminazene molecule.[citation needed]
Resistance
The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993.[3] This likely indicates a permanent loss of function in this area against the tested target, T. congolense isolated from Boran cattle.[3]
References
- ↑ "Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle". The Veterinary Record 118 (26): 722–6. June 1986. doi:10.1136/vr.118.26.722. PMID 3739193.
- ↑ "Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense". Veterinary Parasitology 28 (1–2): 53–64. April 1988. doi:10.1016/0304-4017(88)90018-0. PMID 3388736.
- ↑ 3.0 3.1 "Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia". Acta Tropica (Elsevier BV) 64 (3–4): 205–17. April 1997. doi:10.1016/s0001-706x(96)00645-6. PMID 9107367.
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