Chemistry:Leteprinim
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Short description: Chemical compound
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| Formula | C15H13N5O4 |
| Molar mass | 327.295 g·mol−1 |
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Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects.[1][2][3] It stimulates release of nerve growth factors and enhances survival of neurons in the brain,[4][5][6][7][8] and is under development as a potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke.[9][10]
References
- ↑ "AIT-082 is neuroprotective against kainate-induced neuronal injury in rats". Experimental Neurology 169 (2): 392–9. June 2001. doi:10.1006/exnr.2001.7654. PMID 11358452.
- ↑ "Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin". Annals of the New York Academy of Sciences 903 (1): 387–93. April 2000. doi:10.1111/j.1749-6632.2000.tb06390.x. PMID 10818529. Bibcode: 2000NYASA.903..387L.
- ↑ "Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones". Psychopharmacology 166 (4): 400–7. April 2003. doi:10.1007/s00213-002-1350-5. PMID 12605287.
- ↑ "AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury". Expert Opinion on Investigational Drugs 8 (8): 1255–62. August 1999. doi:10.1517/13543784.8.8.1255. PMID 15992149.
- ↑ "The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats". Restorative Neurology and Neuroscience 20 (1–2): 51–9. 2002. PMID 12237496.
- ↑ "Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin". Molecular and Cellular Neurosciences 24 (3): 568–80. November 2003. doi:10.1016/s1044-7431(03)00217-3. PMID 14664808.
- ↑ "AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats". International Journal of Immunopathology and Pharmacology 17 (3): 353–66. 2004. doi:10.1177/039463200401700315. PMID 15461869.
- ↑ "Protection of sensory function in diabetic rats by Neotrofin". European Journal of Pharmacology 534 (1–3): 187–93. March 2006. doi:10.1016/j.ejphar.2006.01.047. PMID 16507305.
- ↑ "Brain metabolic effects of Neotrofin in patients with Alzheimer's disease". Brain Research 951 (1): 87–95. September 2002. doi:10.1016/s0006-8993(02)03140-2. PMID 12231461.
- ↑ "Drugs in development for Parkinson's disease". Current Opinion in Investigational Drugs 5 (7): 720–6. July 2004. PMID 15298067.
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