Chemistry:Luvadaxistat
From HandWiki
Short description: Chemical compound
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| Other names | TAK-831 |
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| Formula | C13H11F3N2O2 |
| Molar mass | 284.238 g·mol−1 |
Luvadaxistat is an experimental drug that works as a D-amino acid oxidase inhibitor and is supposed to increase NMDA receptor functionality.[1] It is developed to treat Friedrich ataxia[2] and negative symptoms of schizophrenia.[3][4][5]
References
- ↑ O’Donnell, Patricio; Dong, Cheng; Murthy, Venkatesha; Asgharnejad, Mahnaz; Du, Xiaoming; Summerfelt, Ann; Lu, Hong; Xu, Lin et al. (June 2023). "The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial" (in en). Neuropsychopharmacology 48 (7): 1052–1059. doi:10.1038/s41386-023-01560-0. ISSN 1740-634X. PMID 36928351.
- ↑ Wang, Hao; Norton, Jonathan; Xu, Lin; DeMartinis, Nicholas; Sen, Rohini; Shah, Ankit; Farmer, Jennifer; Lynch, David (June 2021). "Results of a randomized double‐blind study evaluating luvadaxistat in adults with Friedreich ataxia". Annals of Clinical and Translational Neurology 8 (6): 1343–1352. doi:10.1002/acn3.51373. PMID 34018342.
- ↑ Fradley, Rosa; Goetghebeur, Pascal; Miller, David; Burley, Russell; Almond, Sarah; Gruart i Massó, Agnès; Delgado García, José M.; Zhu, Bin et al. (October 2023). "Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia". Neurochemical Research 48 (10): 3027–3041. doi:10.1007/s11064-023-03956-2. PMID 37289348.
- ↑ Veselinović, Tanja; Neuner, Irene (August 2022). "Progress and Pitfalls in Developing Agents to Treat Neurocognitive Deficits Associated with Schizophrenia". CNS Drugs 36 (8): 819–858. doi:10.1007/s40263-022-00935-z. PMID 35831706.
- ↑ Kuo, Chien-Yi; Lin, Chieh-Hsin; Lane, Hsien-Yuan (November 2022). "Targeting d-Amino Acid Oxidase (DAAO) for the Treatment of Schizophrenia: Rationale and Current Status of Research". CNS Drugs 36 (11): 1143–1153. doi:10.1007/s40263-022-00959-5. PMID 36194364.
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