Chemistry:NPS-2143
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number |
|
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII |
|
| Chemical and physical data | |
| Formula | C24H25ClN2O2 |
| Molar mass | 408.919 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone.[1] Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.[2][3][4]
See also
References
- ↑ "Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone". The Journal of Pharmacology and Experimental Therapeutics 299 (1): 323–31. October 2001. PMID 11561095.
- ↑ "Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues". Journal of Medicinal Chemistry 52 (13): 3982–93. July 2009. doi:10.1021/jm900364m. PMID 19492813.
- ↑ "Novel calcium sensing receptor ligands: a patent survey". Expert Opinion on Therapeutic Patents 21 (5): 681–98. May 2011. doi:10.1517/13543776.2011.568479. PMID 21406038.
- ↑ "Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators". Pharmacological Research 83: 30–7. May 2014. doi:10.1016/j.phrs.2013.11.006. PMID 24291533.
 |  |
