Chemistry:Omega-atracotoxin

From HandWiki
Omega-atracotoxin
Identifiers
SymbolOmega-toxin
PfamPF06357
InterProIPR009415
SCOP21hvw / SCOPe / SUPFAM

Omega-atracotoxin is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.[1]

References

  1. "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. 2001. doi:10.1074/jbc.M102199200. PMID 11313356. 
This article incorporates text from the public domain Pfam and InterPro: IPR009415