Chemistry:Perimycin

From HandWiki
Perimycin
Perimycin A.png
Names
IUPAC name
(1R,3S,5S,7R,9R,13R,17R,18S,19E,21E,23Z,25Z,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-5-amino-3,4-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,7,9,13,37-heptahydroxy-17-[(2S)-5-hydroxy-7-[4-(methylamino)phenyl]-7-oxoheptan-2-yl]-18,36-dimethyl-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-11,15-dione
Other names
4ʼ-Amino-3ʼ-deamino-18-decarboxy-40-demethyl-4ʼ-deoxy-3,7-dideoxo-3,3ʼ,7-trihydroxy-N47,18,dimethyl-5-oxocandicidin-D-cyclic-15,19-hemiacetal
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C59H88N2O17
Molar mass 1097.33 g/mol
Appearance Amorphous, golden-yellow solid
Melting point Indefinite
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references
Tracking categories (test):

Perimycin, also known as aminomycin and fungimycin, is polyene antibiotic produced by Streptomyces coelicolor var. aminophilus.[1][2][3][4] The compound exhibits antifungal properties.[citation needed]

Composition

Perimycin is produced naturally as a mixture of three types: A, B and C, with type A being the major component. All types consist of a polyketide core with a perosamine sugar moiety. The variations occur at the end of the core opposite the perosamine moiety. Perimycin A has an aromatic group in this position, whereas the identities of the analogous groups in the other perimycin types are currently undetermined.[citation needed]

Usage

Polyene antibiotics in general are often toxic to humans and have poor bioavailability. Thus, with the notable exception of amphotericin B, they are often not used clinically. Perimycin has been shown to be an effective antifungal compound, but is not widely used in clinical settings.[5]

References

  1. Hamilton-Miller JM (June 1973). "Chemistry and biology of the polyene macrolide antibiotics". Bacteriological Reviews 37 (2): 166–96. doi:10.1128/br.37.2.166-196.1973. PMID 4578757. 
  2. "Fungimycin, biogenesis of its aromatic moiety". The Journal of Antibiotics 25 (3): 187–8. March 1972. doi:10.7164/antibiotics.25.187. PMID 5034814. 
  3. "Perimycin. The structure of some degradation products". Tetrahedron 25 (10): 2229–32. May 1969. doi:10.1016/S0040-4020(01)82770-8. PMID 5788396. 
  4. "Stereostructure of perimycin A". The Journal of Antibiotics 48 (9): 1034–8. September 1995. doi:10.7164/antibiotics.48.1034. PMID 7592049. 
  5. Elmer, Y. Tu; Charlotte E. Joslina; Lisa M. Nijmc; Robert S. Federd; Sandeep Jaina; Megan E. Shoffe (July 2009). "Polymicrobial Keratitis: Acanthamoeba and Infectious Crystalline Keratopathy". American Journal of Ophthalmology 148 (1): 13–19.e2. doi:10.1016/j.ajo.2009.01.020. PMID 19327742.