Chemistry:Phenylpiperidines

Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity or other central nervous system effects.

"Phenyl"piperidines

Compound	N	4-position	3-position	4'-position	Type of pharmacology
MPPP	Me	Ph	H	–OCOEt	Opioid analgesic
Prodine	Me	Ph	Me	–OCOEt	Opioid analgesic
PEPAP	CH2CH2Ph	Ph	H	–OCOMe	Opioid analgesic
Pethidine	Me	Ph	H	–CO2Et	mu-Agonist with serotonin reuptake inhibitor properties
Budipine	t-Bu	Ph	H	Ph	Antiparkinson agent
Ketobemidone	Me	3-HO–Ph	H	–COEt	Opioid and NMDA antagonist
Paroxetine	H	4-F–Ph	–CH2OAr	H	Selective serotonin reuptake inhibitor (and norepinephrine transporter)
Femoxetine	Me	Ph	–CH2O(4-MeOPh)	H	Selective serotonin reuptake inhibitor
CPCA	Me	4-Cl–Ph	–CO2Me	H	Monoamine reuptake inhibitor

Methylphenidate is a benzylpiperidine.