Chemistry:Pimitespib
From HandWiki
Short description: Gastrointestinal drug
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| Trade names | Jeselhy |
| Other names | TAS 116 |
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| Formula | C25H26N8O |
| Molar mass | 454.538 g·mol−1 |
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Pimitespib (trade name Jeselhy) is a drug for the treatment of gastrointestinal stromal tumors.[1] It was discovered and developed by Taiho Pharmaceutical Co.[2] The mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90).[3]
In June 2022, it received approval in Japan for gastrointestinal stromal tumors that have progressed after chemotherapy.[4]
References
- ↑ "Pimitespib - Taiho Pharmaceutical". Adis Insight. https://adisinsight.springer.com/drugs/800041893.
- ↑ "Taiho Pharmaceutical Obtains Approval to Manufacture and Market HSP90 inhibitor Jeselhy® Tablets 40 mg (Pimitespib) for Gastrointestinal Stromal Tumor (GIST)" (Press release). Taiho Pharmaceutical. June 20, 2022.
- ↑ "Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial". Annals of Oncology 33 (9): 959–967. June 2022. doi:10.1016/j.annonc.2022.05.518. PMID 35688358.
- ↑ "Pimitespib: First Approval". Drugs 82 (13): 1413–1418. August 2022. doi:10.1007/s40265-022-01764-6. PMID 35986838. https://figshare.com/articles/online_resource/Pimitespib_First_Approval/20435979.
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