Chemistry:S416
From HandWiki
Short description: Chemical compound
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| Formula | C18H14ClN3O2S |
| Molar mass | 371.84 g·mol−1 |
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S416 (GTPL-11164) is a drug which acts as a selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme is involved in the synthesis of pyrimidine nucleosides in the body, which are required for the synthesis of DNA and RNA. This is an important rate-limiting step in the replication of viruses, and so DHODH inhibitors may have applications as broad-spectrum antiviral drugs. In tests in vitro, S416 was found to have antiviral activity against a range of pathogenic RNA viruses including influenza, Zika virus, Ebola virus and SARS-CoV-2.[1][2]
See also
References
- ↑ "Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2". Protein & Cell 11 (10): 723–739. October 2020. doi:10.1007/s13238-020-00768-w. PMID 32754890.
- ↑ "An update review of emerging small-molecule therapeutic options for COVID-19". Biomedicine & Pharmacotherapy 137: 111313. May 2021. doi:10.1016/j.biopha.2021.111313. PMID 33556871.
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