Chemistry:Selutaront
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Selutaront is a trace amine-associated receptor 1 (TAAR1) agonist which is being investigated for the potential treatment of schizophrenia.[1] It is a highly selective, low-potency, high-efficacy partial agonist of the human TAAR1 (EC50 = 2,330 nM; Emax = 83%).[1] The drug shows antipsychotic-like effects in rodents, such as antagonism of dizocilpine (MK-801)-induced hyperlocomotion, without affecting spontaneous locomotor activity when given by itself.[1] The chemical synthesis of selutaront has been described.[1] Selutaront was first described in the scientific literature by Jianzhao Zhang and colleagues in 2026.[1]
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