Chemistry:Sobetirome
From HandWiki
Short description: Chemical compound
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| Other names | GC-1 |
| Routes of administration | Oral |
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| Formula | C20H24O4 |
| Molar mass | 328.408 g·mol−1 |
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Sobetirome (GC-1) is a thyromimetic drug that binds to the thyroid hormone receptor TRβ1 preferentially compared to TRα1. It has been investigated for the treatment of dyslipidemia, obesity,[1] Pitt–Hopkins syndrome,[2] cholestatic liver disease,[3] multiple sclerosis,[4] bleomycin-induced lung fibrosis,[5] and COVID-19 caused ARDS.[6] It was designated as an orphan drug by the FDA for the treatment of X-linked adrenoleukodystrophy.[7]
References
- ↑ Lammel Lindemann, Jan; Webb, Paul (2016). "Sobetirome: the past, present and questions about the future". Expert Opinion on Therapeutic Targets 20 (2): 145–149. doi:10.1517/14728222.2016.1090429. ISSN 1744-7631. PMID 26565124.
- ↑ Bohlen, Joseph F; Cleary, Colin M; Das, Debamitra; Sripathy, Srinidhi Rao; Sadowski, Norah; Shim, Gina; Kenney, Rakaia F; Buchler, Ingrid P et al. (1 August 2023). "Promyelinating drugs promote functional recovery in an autism spectrum disorder mouse model of Pitt–Hopkins syndrome". Brain 146 (8): 3331–3346. doi:10.1093/brain/awad057. PMID 37068912. PMC 10393406. https://academic.oup.com/brain/article/146/8/3331/7116255.
- ↑ Kosar, Karis; Cornuet, Pamela; Singh, Sucha; Liu, Silvia; Nejak-Bowen, Kari (May 2020). "The Thyromimetic Sobetirome (GC-1) Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis". The American Journal of Pathology 190 (5): 1006–1017. doi:10.1016/j.ajpath.2020.01.015. ISSN 0002-9440. PMID 32205094.
- ↑ Shah, Kamal; Chauhan, Durgesh Nandini; Chauhan, Nagendra Singh; Mishra, Pradeep (13 May 2020) (in en). Recent Advancement in Prodrugs. CRC Press. ISBN 978-1-000-05799-7. https://books.google.com/books?id=nWbnDwAAQBAJ&pg=SA4-PA80.
- ↑ Matralis, Alexios; Karampitsakos, Theodoros; Papaioannou, Ourania; Katsaras, Matthaios; Sampsonas, Fotios; Bouros, Demosthenes; Aidinis, Vassilis; Tzouvelekis, Argyrios (5 September 2021). "Biosynthesis and implementation of Thyroid Receptor beta (TRß) agonists (thyromimetics) for the treatment of pulmonary fibrosis" (in en). European Respiratory Journal 58 (suppl 65): OA4334. doi:10.1183/13993003.congress-2021.OA4334. ISSN 0903-1936. https://erj.ersjournals.com/content/58/suppl_65/OA4334.abstract.
- ↑ Hartley, Pamela. "$100,000 Gift Speeds Exploration of Sobetirome as COVID-19 Treatment" (in en). https://medicine.yale.edu/news-article/100000-gift-speeds-exploration-of-sobetirome-as-covid-19-treatment/.
- ↑ "Search Orphan Drug Designations and Approvals". https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=334811.
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