Chemistry:Telomestatin
From HandWiki
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| Preferred IUPAC name
(84R)-65,75-Dimethyl-84,85-dihydro-1(2,4),2,3,4,5,6,7(4,2)-heptakis([1,3]oxazolo)-8(2,4)-[1,3]thiazolocyclooctaphane | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C26H14N8O7S | |
| Molar mass | 582.51 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells.[1] It was first isolated from the bacteria Streptomyces anulatus.[1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
References
- ↑ 1.0 1.1 Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo (2001). "Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus". Journal of the American Chemical Society 123 (6): 1262–1263. doi:10.1021/ja005780q. PMID 11456694.
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