Chemistry:Thiazovivin
From HandWiki
Short description: Chemical compound
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| Formula | C15H13N5OS |
| Molar mass | 311.36 g·mol−1 |
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Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications.[1][2][3][4]
See also
References
- ↑ "A chemical platform for improved induction of human iPSCs". Nature Methods 6 (11): 805–8. November 2009. doi:10.1038/nmeth.1393. PMID 19838168.
- ↑ "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology 67 (2): 191–7. March 2015. doi:10.1007/s10616-013-9686-8. PMID 24682663.
- ↑ "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International 39 (5): 515–8. May 2015. doi:10.1002/cbin.10411. PMID 25490878.
- ↑ "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience 10: 348. 2017. doi:10.3389/fnmol.2017.00348. PMID 29163026.
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