Chemistry:Tilorone
From HandWiki
Short description: Chemical compound
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| Clinical data | |
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth (tablets) |
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| Pharmacokinetic data | |
| Bioavailability | 60% |
| Protein binding | ~80% |
| Metabolism | Nil |
| Elimination half-life | 48 hours |
| Excretion | Feces (70%), urine (9%)[1] |
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| Chemical and physical data | |
| Formula | C25H34N2O3 |
| Molar mass | 410.558 g·mol−1 |
| 3D model (JSmol) | |
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Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.[2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.[3]
Pharmacology
Tilorone activates the production of interferon.[2]
References
- ↑ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). http://www.rlsnet.ru/mnn_index_id_2731.htm.
- ↑ 2.0 2.1 "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy 2 (2): 73–78. August 1972. doi:10.1128/aac.2.2.73. PMID 4670490.
- ↑ "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy 62 (2). February 2018. doi:10.1128/AAC.01711-17. PMID 29133569.
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