Chemistry:Trafermin
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Short description: Medication
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| Trade names | Fiblast |
| Other names | CAB-2001; Recombinant human basic fibroblast growth factor; rhbFGF; 2-155-Basic fibroblast growth factor (human clone lambdaKB7/lambdaHFL1 precursor reduced) |
| Routes of administration | Topical (spray)[1] |
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| Chemical and physical data | |
| Formula | C764H1201N217O219S6 |
| Molar mass | 17122.67 g·mol−1 |
Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in Japan as a topical spray for the treatment of skin ulcers.[2][3][1] It is also currently in preregistration for the treatment of periodontitis.[2][4] As a recombinant form of bFGF, trafermin is a potent agonist of the FGFR1, FGFR2, FGFR3, and FGFR4.[5][6] The drug has been marketed in Japan since June 2001.[7]
References
- ↑ 1.0 1.1 "Growth Factor Therapy". Innovations and Advances in Wound Healing. Springer. 15 September 2015. pp. 206–. ISBN 978-3-662-46587-5. https://books.google.com/books?id=IY-QCgAAQBAJ&pg=PA206.
- ↑ 2.0 2.1 "Trafermin - Kaken Pharmaceutical". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800009962.
- ↑ "Trafermin". Drugs.com. https://www.drugs.com/international/trafermin.html.
- ↑ "Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects". Journal of Bone and Mineral Research 31 (4): 806–814. April 2016. doi:10.1002/jbmr.2738. PMID 26547659.
- ↑ "Growth Factors in the Gastrointestinal Tract". Physiology of the Gastrointestinal Tract. Academic Press. 10 May 2006. pp. 216–. ISBN 978-0-08-045615-7. https://books.google.com/books?id=CNwLlih2C60C&pg=PA216.
- ↑ Hamid M. Said (4 July 2012). Physiology of the Gastrointestinal Tract, Two Volume Set. Academic Press. pp. 235–. ISBN 978-0-12-382027-3. https://books.google.com/books?id=ytWBLAy1FGQC&pg=PA235.
- ↑ "Rationale for basic FGF in wound healing and review of therapeutic applications.". European Journal of Pharmaceutical and Medical Research 3: 51–59. 2016. https://www.ejpmr.com/home/abstract_id/983.
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