Chemistry:Trimix (drug)
| Combination of | |
|---|---|
| Alprostadil | prostaglandin |
| Papaverine | vasodilator |
| Phentolamine | alpha blocker |
| Clinical data | |
| Pregnancy category |
|
| Routes of administration | injection, intraurethral, topical |
| Legal status | |
| Legal status |
|
| Identifiers | |
| ChemSpider |
|
| (verify) | |
Trimix is a prescription combination drug containing alprostadil, papaverine, and phentolamine. It is used to treat erectile dysfunction.[1][2][3]
Medical use
Available forms
Trimix is available in several different formulations, including a gel that can be used topically, a gel that can be administered into the urethra, and an injectable form that is administered via intracavernosal injection (an injection at either side, not the base, of the penis).[2][4][5][6]
Adverse effects
Adverse effects from injecting Trimix may include pain, fibrosis, hematoma, and priapism (a prolonged erection of the penis).[3]
Pharmacology
Trimix is a combination of three drugs: alprostadil, papaverine, and phentolamine. These medications work in combination to increase blood flow to the penis, resulting in an erection.[1][2][3] Alprostadil is a prostaglandin vasodilator that allows more blood to flow into the area by relaxing the smooth muscle in the blood vessels of the penis.[3][7] Papaverine is a smooth muscle relaxant that acts by increasing blood flow to the penis.[3][8] Phentolamine is an alpha blocker that relaxes blood vessel muscles, allowing more blood to flow to the penis.[3][9]
Society and culture
Availability
While the active drugs in Trimix have all been individually approved by the U.S. Food and Drug Administration (FDA), Trimix as a combination drug has not been approved by the FDA and is only available from compounding pharmacies.[1][3][10] Trimix is typically prepared by the compounding pharmacy in a sterile environment and then frozen.[11] The compound is stable for up to six months while stored frozen and for one month if stored refrigerated beginning at the time of manufacture.[12]
References
- ↑ 1.0 1.1 1.2 "Current status of intracavernosal injection therapy in erectile dysfunction". Expert Opinion on Pharmacotherapy 24 (8): 925–933. June 2023. doi:10.1080/14656566.2023.2204189. PMID 37078428.
- ↑ 2.0 2.1 2.2 "Studies with Trimix gel in men who failed phosphodiesterase inhibitors". Journal of Urology 179 (4S): 431. May 2008. doi:10.1016/s0022-5347(08)61264-1. ISSN 0022-5347. https://www.auajournals.org/doi/pdf/10.1016/S0022-5347%2808%2961264-1.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 "Erectile dysfunction: a global review of intracavernosal injectables". World Journal of Urology 37 (6): 1007–1014. June 2019. doi:10.1007/s00345-019-02727-5. PMID 30895359.
- ↑ "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research 17 (4): 346–353. 2005. doi:10.1038/sj.ijir.3901313. PMID 15772683.
- ↑ "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International 92 (3): 277–280. August 2003. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483.
- ↑ "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology 93 (6): 689–693. March 2004. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.
- ↑ "Alprostadil". StatPearls. Treasure Island (FL): StatPearls Publishing. 18 July 2022. https://www.ncbi.nlm.nih.gov/books/NBK542217/. Retrieved 24 April 2023.
- ↑ "Papaverine topical gel for treatment of erectile dysfunction". The Journal of Urology 153 (2): 361–365. February 1995. doi:10.1097/00005392-199502000-00019. PMID 7815584.
- ↑ "Intracavernous pharmacotherapy for erectile dysfunction". Endocrine 23 (2–3): 149–155. 2004. doi:10.1385/ENDO:23:2-3:149. PMID 15146094. "The vasoactive potential of phentolamine was discovered in 1978, with early animal studies suggesting effective blockade of the epinephrine pressor response and a smaller sympatholytic effect (63). An alpha-adrenergic antagonist with equal affinity for α1 and α2 receptors, monotherapy with phentolamine has been disappointing. It is hypothesized that although intracavernous injection of phentolamine increases corporal blood flow, a concurrent increase in norepinephrine prevent sinusoidal relaxation.".
- ↑ "What to Know About Trimix Injections for Erectile Dysfunction". 28 January 2022. https://www.goodrx.com/conditions/erectile-dysfunction/trimix-injections-erectile-dysfunction.
- ↑ "Alprostadil / Papaverine / Phentolamine 20mcg-30mg-1mg/ml Injection Solution (Tri-Mix) | Formulas | My Dashboard". Bayview Pharmacy. https://www.bayviewrx.com/formulas/rec7COK9TaoQTRYU4.
- ↑ "Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction". International Journal of Pharmaceutical Compounding 8 (3): 231–235. 2004. PMID 23924676.
External links
- "Erectile Dysfunction: Trimix Injections". University of Utah. 6 April 2021. https://healthcare.utah.edu/menshealth/conditions/erectile-dysfunction/trimix-injection.
 |  |
