Chemistry:Troriluzole
From HandWiki
Troriluzole is an experimental medication that has been investigated as a potential treatment for Machado–Joseph disease (MJD),[1] obsessive–compulsive disorder (OCD),[2][3] and glioblastoma.[4] It is a prodrug formulation of the medication riluzole.[2][4]
Pharmacology
Pharmacokinetics
While riluzole is typically taken twice-daily and on an empty stomach, troriluzole may offer a potential once-daily dosing with or without food along with greater bioavailability.[2][4]
Research
In 2024, researchers published a study in the Journal of Neurochemistry that reported troriluzole could reverse some early Alzheimer's disease brain changes in mice, reduce harmful glutamate levels, and improve memory and learning abilities.[5][6]
References
- ↑ Meglio, Marco (25 June 2023). "Biohaven Submits New Drug Application for Troriluzole as Spinocerebellar Ataxia Type 3 Therapy". https://www.neurologylive.com/view/biohaven-submits-new-drug-application-for-troriluzole-spinocerebellar-ataxia-type-3-therapy.
- ↑ 2.0 2.1 2.2 "Investigational and Experimental Drugs to Treat Obsessive-Compulsive Disorder". Journal of Experimental Pharmacology 12: 695–706. 2020. doi:10.2147/JEP.S255375. PMID 33447096.
- ↑ "Treatment-resistant OCD: Pharmacotherapies in adults". Comprehensive Psychiatry 120. January 2023. doi:10.1016/j.comppsych.2022.152352. PMID 36368186.
- ↑ 4.0 4.1 4.2 "A phase Ib dose-escalation study of troriluzole (BHV-4157), an oral glutamatergic signaling modulator, in combination with nivolumab in patients with advanced solid tumors". European Journal of Medical Research 27 (1): 107. July 2022. doi:10.1186/s40001-022-00732-w. PMID 35780243.
- ↑ "Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice". Journal of Neurochemistry. August 2024. doi:10.1111/jnc.16215. PMID 39214859.
- ↑ "New Drug Shows Promise in Reversing Memory Loss and Cognitive Decline". SciTech. September 5, 2024. https://scitechdaily.com/alzheimers-breakthrough-new-drug-shows-promise-in-reversing-memory-loss-and-cognitive-decline/.
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