Chemistry:Vitamin D analogues
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Short description: Group of chemical compounds
The active natural hormonal form of vitamin D is 1,25-dihydroxyvitamin D (1,25(OH)2D). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions.[1][2][3][4]
Types
These include:
- Alfacalcidol
- Calcipotriol (calcipotriene)
- Doxercalciferol
- Falecalcitriol
- Paricalcitol
- Tacalcitol
Mechanisms
These modified vitamin D analogues have side chain or other modifications. They aim to reduce the classical renal and intestinal effects of calcitriol on calcium and phosphate homeostasis, from its effects on other biologic processes.[5] They target cell proliferation and differentiation, especially in skin, or other effects in the parathyroid gland (secondary hyperparathyroidism) or bone cells.[5]
References
- ↑ "Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis". BMJ (Clinical Research Ed.) 320 (7240): 963–7. April 2000. doi:10.1136/bmj.320.7240.963. PMID 10753146.
- ↑ "Vitamin D analogues for the management of secondary hyperparathyroidism". American Journal of Kidney Diseases 38 (5 Suppl 5): S34–40. November 2001. doi:10.1053/ajkd.2001.28109. PMID 11689385.
- ↑ "Vitamine D analogue-based therapies for psoriasis". Drugs of Today 46 (5): 351–60. May 2010. doi:10.1358/dot.2010.46.5.1473264. PMID 20517536.
- ↑ "Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation". Current Drug Targets 9 (4): 345–59. April 2008. doi:10.2174/138945008783954970. PMID 18393827.
- ↑ 5.0 5.1 "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology 21 (3): 319–29. March 2014. doi:10.1016/j.chembiol.2013.12.016. PMID 24529992.
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