Chemistry:WAY-267464
 | |
| Clinical data | |
|---|---|
| Routes of administration | ? |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C32H35N7O4 |
| Molar mass | 581.677 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
WAY-267464 is a potent, selective, non-peptide agonist for the oxytocin receptor, with negligible affinity for the vasopressin receptors.[1][2] Contradictorily however, though originally described as selective for the oxytocin receptor and lacking affinity for the vasopressin receptors, it has since been reported to also act as a potent vasopressin V1A receptor antagonist (in contrast to oxytocin, which is a weak agonist of the V1A receptor).[3] WAY-267464 has been shown to cross the blood–brain barrier to a significantly greater extent than exogenously applied oxytocin, and in animal tests produces centrally-mediated oxytocinergic actions such as anxiolytic effects, but with no antidepressant effect evident.[4] It was developed by a team at Ferring Pharmaceuticals.[5] WAY-267464 was under investigation for the potential clinical treatment of anxiety disorders by Wyeth, and reached the preclinical stage of development, but no development has been reported as of 2011.[6]
See also
References
- ↑ Rahman Z, Resnick L, Rosenzweig-Lipson SJ, Ring RH,"Methods of treatment using oxytocin receptor agonists", US patent application 2007/0117794, published 2007-05-24 , assigned to Wyeth Corp
- ↑ "Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: Research tools and potential therapeutic agents☆". Advances in Vasopressin and Oxytocin — from Genes to Behaviour to Disease. Progress in Brain Research. 170. 2008. pp. 473–512. doi:10.1016/S0079-6123(08)00437-8. ISBN 9780444532015.
- ↑ "Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats". Br. J. Pharmacol. 171 (11): 2868–87. June 2014. doi:10.1111/bph.12613. PMID 24641248.
- ↑ "Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist". Neuropharmacology 58 (1): 69–77. July 2009. doi:10.1016/j.neuropharm.2009.07.016. PMID 19615387.
- ↑ European Patent 1512687 Piperazines as oxytocin agonists
- ↑ "Research programme: Oxytocin receptor agonist - Wyeth - AdisInsight". http://adisinsight.springer.com/drugs/800029344.
 |  |
