Chemistry:Zabedosertib
From HandWiki
Zabedosertib (BAY 1834845) is an experimental drug which acts as a selective inhibitor of the enzyme interleukin‐1 receptor‐associated kinase 4 (IRAK4). It has antiinflammatory effects and is being researched for possible applications in treating inflammatory conditions of the skin.[1][2][3]
See also
- Emavusertib
- Zimlovisertib
References
- ↑ "USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis". Microbes and Infection 23 (9–10). 2021. doi:10.1016/j.micinf.2021.104867. PMID 34298177.
- ↑ "Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839". Journal of Medicinal Chemistry 67 (2): 1225–1242. January 2024. doi:10.1021/acs.jmedchem.3c01714. PMID 38228402.
- ↑ "The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers". Clinical and Translational Science 17 (3). March 2024. doi:10.1111/cts.13771. PMID 38511583.
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