Company:MedImmune

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Short description: Biopharmaceutical company, acquired by AstraZeneca in 2007
MedImmune, LLC
TypeSubsidiary
IndustryPharmaceutical
Founded1988; 36 years ago (1988) (as Molecular Vaccines, Inc.)
1989; 35 years ago (1989) (as MedImmune, Inc.)
HeadquartersGaithersburg, Maryland, United States
ProductsSynagis
FluMist
ParentAstraZeneca
Websitewww.medimmune.com[|permanent dead link|dead link}}]

MedImmune, LLC was a wholly owned subsidiary of AstraZeneca before February 14, 2019, when it was announced that the MedImmune name and branding would be discontinued in favor of AstraZeneca.[1][2]

MedImmune was founded in 1988 as Molecular Vaccines, Inc, and was purchased in 2007 for $15.6 billion.[3] Its main offices were located in Gaithersburg, MD, Cambridge, UK, and Mountain View, CA.[4]

It produced Synagis, a drug for the prevention of respiratory infections in infants, which accounted for United States dollar 1.06 billion of its United States dollar 1.2 billion in revenue for 2005, and FluMist, a nasal spray influenza vaccine introduced in 2004. MedImmune acquired FluMist when it purchased Aviron in 2002 for United States dollar 1.5 billion. FluMist sales totaled United States dollar 104 million in 2008, United States dollar 54.8 million in 2007, and United States dollar 36.4 million in 2006.[5]

FluMist was approved for children two years of age and older in 2007, but initially was approved only for healthy people ages 5 to 49, a significant limitation because it eliminated a significant market—young children who find injections objectionable. Sales of FluMist fell short of analysts' expectations for the first two years the drug was sold. FluMist was initially sold in a frozen form, which was difficult for doctors to store.[6]

MedImmune conducted successful clinical trials for a new generation of FluMist needle-free vaccine, called CAIV-T, which was approved by the U.S. Food and Drug Administration (FDA) in 2007, and is now the form offered on the market.

History

Molecular Vaccines, Inc. was founded by Wayne T. Hockmeyer, David Mott, and Dr. James Young in 1988.[6] In 1989, Molecular Vaccines, Inc changed its name to MedImmune, Inc.

On April 23, 2007, it was announced MedImmune and AstraZeneca entered into a definitive agreement under which AstraZeneca intended to acquire MedImmune in an all-cash transaction at United States dollar 58 per share, or about United States dollar 15.2 billion.[6] On 19 June 2007 AstraZeneca completed the acquisition paying United States dollar 15.2 billion primarily for its drug development pipeline. Analysts have criticised the take-over, claiming that AstraZeneca paid too much.[7] AstraZeneca chose to merge MedImmune with Cambridge Antibody Technology, which it had acquired in 2006, creating a new biologics division under the MedImmune name. AstraZeneca presented the new MedImmune to investors on 7 December 2007.[8]

In June 2007, the National Institutes of Health (NIH) began enrolling participants in a Phase 1 H5N1 study of an intranasal influenza vaccine candidate based on MedImmune's live, attenuated vaccine technology.[9]

MedImmune said it was making a significant, rapid response with a vaccine to the novel H1N1 variant of influenza, known as swine flu.[10] In June 2009 it won a Department of Health and Human Services (HHS) contract, worth $90m. Under the contract with HHS, MedImmune will continue to make its seasonal FluMist vaccine and also develop a vaccine targeted specifically at the novel H1N1 virus.[5] MedImmune then won a second contract to test its nasal spray flu technology as a viable treatment for the H1N1.[11]

MedImmune received approval from the U.S. FDA for its intranasal novel H1N1 influenza vaccine in September 2009.[10]

Pipeline

MedImmune had over 120 drugs in development for conditions including lupus, COPD, asthma, and many types of cancer. Major phase III trials included:[12]

See also

  • MedImmune, Inc. v. Genentech, Inc.

References and notes

  1. ↑ "12 years on, Astra draws a line under Medimmune" (in en). 2019-02-14. http://www.evaluate.com/vantage/articles/news/corporate-strategy/12-years-astra-draws-line-under-medimmune. 
  2. ↑ "AstraZeneca retires Medimmune name amid sales turnaround" (in en-US). https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/. 
  3. ↑ Pollack, Andrew (24 April 2007). "AstraZeneca Buys MedImmune for $15.6 Billion". https://www.nytimes.com/2007/04/24/business/24drug-web.html. 
  4. ↑ "About Us | MedImmune". https://www.medimmune.com/about-us.html. 
  5. ↑ 5.0 5.1 Michael S. Rosenwald (June 2, 2009). "MedImmune Wins Key Contract To Develop Swine Flu Vaccine". The Washington Post. https://www.washingtonpost.com/wp-dyn/content/article/2009/06/01/AR2009060101608.html. 
  6. ↑ 6.0 6.1 6.2
  7. ↑ "AstraZeneca's $15 Billion Buy of MedImmune buy too costly, some say". https://money.cnn.com/2007/04/23/news/companies/astrazeneca/index.htm. 
  8. ↑ "Media Centre - AstraZeneca". https://www.astrazeneca.com/media-centre.html. 
  9. ↑ MedImmune Press release MedImmune and National Institutes of Health Begin Clinical Testing of a Live, Attenuated Intranasal Vaccine Against an H5N1 Avian Influenza Virus published June 15, 2007
  10. ↑ 10.0 10.1 "MedImmune Influenza A (H1N1) Information". http://www.medimmune.com/h1n1.aspx. 
  11. ↑ Sinha, Vandana (13 July 2009). "MedImmune gets second H1N1 flu contract". http://www.bizjournals.com/washington/stories/2009/07/13/daily21.html. 
  12. ↑ "Pipeline - AstraZeneca". https://www.astrazeneca.com/our-science/pipeline.html. 

External links



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