Chemistry:Omeprazole

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Short description: Medication to treat gastroesophageal reflux disease and other conditions
Omeprazole
Omeprazole.svg
Omeprazole-3D-balls.png
Clinical data
Pronunciation/oʊˈmɛprəzoʊl/
Trade namesLosec, Prilosec, others[1][2]
AHFS/Drugs.comMonograph
MedlinePlusa693050
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous
Drug classProton-pump inhibitor
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability35–76%[4][5]
Protein binding95%
MetabolismLiver (CYP2C19, CYP3A4)
Elimination half-life1–1.2 hours
Excretion80% (urine)
20% (bile via feces)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC17H19N3O3S
Molar mass345.42 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
Density1.4±0.1[6] g/cm3
Melting point156 °C (313 °F)
  (verify)

Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome.[1] It is also used to prevent upper gastrointestinal bleeding in people who are at high risk.[1] Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs.[7] It can be taken by mouth or by injection into a vein.[1][8] It is also available in the fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid[9][10] and as Konvomep.[11]

Common side effects include nausea, vomiting, headaches, abdominal pain, and increased intestinal gas.[1][12] Serious side effects may include Clostridium difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer.[1] Whether it is safe for use in pregnancy is unclear.[1] It works by blocking the release of stomach acid.[1]

Omeprazole was patented in 1978, and approved for medical use in 1988.[13][14] It is on the World Health Organization's List of Essential Medicines.[15] It is available as a generic medication.[1] In 2021, it was the eighth-most commonly prescribed medication in the United States, with more than 54 million prescriptions.[16][17] It is also available without a prescription in the United States.[18][19]

Medical uses

Omeprazole can be used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, Zollinger–Ellison syndrome, and eosinophilic esophagitis.[20][1]

Peptic ulcers

Peptic ulcers may be treated with omeprazole. Infection with Helicobacter pylori can be treated by taking omeprazole, amoxicillin, and clarithromycin together for 7–14 days.[21] Amoxicillin may be replaced with metronidazole in patients who are allergic to penicillin.[22]

Adverse effects

Adverse effects occurring in at least 1% of people include:[23][failed verification]

  • Central nervous system: headache (7%), dizziness (2%)
  • Respiratory: upper respiratory tract infection (2%), cough (1%)
  • Gastrointestinal: abdominal pain (5%), diarrhea (4%), nausea (4%), vomiting (3%), flatulence (3%), acid regurgitation (2%), constipation (2%)
  • Neuromuscular and skeletal: back pain (1%), weakness (1%)
  • Dermatologic: rash (2%)

Other concerns related to adverse effects are:

Concern has been expressed regarding vitamin B12[28] and iron malabsorption,[29] but effects seem to be insignificant, especially when supplement therapy is provided.[30]

Since their introduction, proton-pump inhibitors (PPIs, especially omeprazole) have also been associated with several cases of acute interstitial nephritis,[31] an inflammation of the kidneys that often occurs as an adverse drug reaction.

Long-term use

Long-term use of PPIs is strongly associated with the development of benign polyps from fundic glands (which is distinct from fundic gland polyposis); these polyps do not cause cancer and resolve when PPIs are discontinued. No association is seen between PPI use and cancer, but use of PPIs may mask gastric cancers or other serious gastric problems and physicians should be aware of this effect.[32]

There is a possible association between long term use and dementia which requires further study to confirm.[33]

A review article in U.S. Pharmacist in 2013 states that long-term use of PPIs is associated with decreased calcium absorption (causing increased risk of osteoporosis and fractures), decreased magnesium absorption (causing electrolyte disturbances), and increased risk of certain infections such as C. difficile and community-acquired pneumonia. They hypothesize that this is due to decreased stomach acid production.[34]

Pregnancy and breastfeeding

The safety of using omeprazole has not been established in pregnant or breastfeeding women.[12] Epidemiological data do not show an increased risk of major birth defects after maternal use of omeprazole during pregnancy.[35]

Interactions

Omeprazol Actavis 20 mg, bottle and pills in Sweden

Important drug interactions are rare.[36][37] However, the most significant major drug interaction concern is the decreased activation of clopidogrel when taken together with omeprazole.[38] Although still controversial,[39] this may increase the risk of stroke or heart attack in people taking clopidogrel to prevent these events.

This interaction is possible because omeprazole is an inhibitor of the enzymes CYP2C19 and CYP3A4.[40] Clopidogrel is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form. Inhibition of CYP2C19 may block the activation of clopidogrel, which could reduce its effects.[41][42]

Almost all benzodiazepines are metabolised by the CYP3A4 and CYP2D6 pathways, and inhibition of these enzymes results in a higher area under the curve (i.e., the total effect over time of a given dose). Other examples of drugs dependent on CYP3A4 for their metabolism are escitalopram,[43] warfarin,[44] oxycodone, tramadol, and oxymorphone. The concentrations of these drugs may increase if they are used concomitantly with omeprazole.[45]

Omeprazole is also a competitive inhibitor of p-glycoprotein, as are other PPIs.[46]

Drugs that depend on an acidic stomach environment (such as ketoconazole or atazanavir) may be poorly absorbed, whereas acid-labile antibiotics (such as erythromycin which is a very strong CYP3A4 inhibitor) may be absorbed to a greater extent than normal due to the more alkaline environment of the stomach.[45]

St. John's wort (Hypericum perforatum) and Ginkgo biloba significantly reduce plasma concentrations of omeprazole through induction of CYP3A4 and CYP2C19.[47]

Proton-pump inhibitors like omeprazole have been found to increase the plasma concentrations of methotrexate.[48]

Pharmacology

Omeprazole irreversibly blocks the enzyme system on parietal cells that is needed for the secretion of gastric acid. It is a specific H+/K+ATPase inhibitor. This is the enzyme needed for the final step in the secretion of gastric acid.[49]

Mechanism of action

Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production.[49]

Omeprazole also inhibits both basal and stimulated acid secretion irrespective of the stimulus[50] as it blocks the last step in acid secretion.[50] The drug binds non-competitively so it has a dose-dependent effect.[51]

The inhibitory effect of omeprazole occurs within 1 hour after oral administration. The maximum effect occurs within 2 hours. The duration of inhibition is up to 72 hours. When omeprazole is stopped, baseline stomach acid secretory activity returns after 3 to 5 days. The inhibitory effect of omeprazole on acid secretion will plateau after 4 days of repeated daily dosing.[52]

Pharmacokinetics

The absorption of omeprazole takes place in the small intestine and is usually completed within 3 to 6 hours. The systemic bioavailability of omeprazole after repeated doses is about 60%.[53] Omeprazole has a volume of distribution of 0.4 L/kg. It has high plasma protein binding of 95%.[51]

Omeprazole, as well as other PPIs, are only effective on active H+/K+-ATPase pumps. These pumps are stimulated in the presence of food to aid in digestion. For this reason, patients should be advised to take omeprazole with a glass of water on an empty stomach.[54] Additionally, most sources recommend that after taking omeprazole, at least 30 minutes should be allowed to elapse before eating[55][56] (at least 60 minutes for immediate-release omeprazole plus sodium bicarbonate products, such as Zegerid),[10]

Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver, by CYP2C19 and CYP3A4 isoenzymes.[12] Identified metabolites are the sulfone, the sulfide, and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 77% of an orally given dose is excreted as metabolites in the urine, and the remainder is found in the feces, primarily originating from bile secretion.[50] Omeprazole has a half life of 0.5 to 1 hour.[50]

Chemistry

Omeprazole contains a tricoordinated sulfonyl sulfur in a pyramidal structure and therefore can exist as either the (S)- or (R)-enantiomers. Omeprazole is a racemate, an equal mixture of the two. In the acidic conditions of the canaliculi of parietal cells, both enantiomers are converted to achiral products (sulfenic acid and sulfenamide configurations) which react with a cysteine group in H+/K+ ATPase, thereby inhibiting the ability of the parietal cells to produce gastric acid.[citation needed]

Omeprazol rearrangement in the body

AstraZeneca also developed esomeprazole (Nexium) which is a eutomer, purely the (S)-enantiomer, rather than a racemate like omeprazole.

Omeprazole undergoes a chiral shift in vivo which converts the inactive (R)-enantiomer to the active (S)-enantiomer, doubling the concentration of the active form.[57] This chiral shift is accomplished by the CYP2C19 isozyme of cytochrome P450, which is not found equally in all human populations. Those who do not metabolize the drug effectively are called "poor metabolizers". The proportion of the poor metabolizer phenotype varies widely between populations, from 2.0 to 2.5% in African Americans and white Americans to >20% in Asians. Several pharmacogenomics studies have suggested that PPI treatment should be tailored according to CYP2C19 metabolism status.[58]

Measurement in body fluids

Omeprazole may be quantified in plasma or serum to monitor therapy or to confirm a diagnosis of poisoning in hospitalized patients. Plasma omeprazole concentrations are usually in a range of 0.2–1.2 mg/L in persons receiving the drug therapeutically by the oral route and 1–6 mg/L in people with acute overdose. Enantiomeric chromatographic methods are available to distinguish esomeprazole from racemic omeprazole.[59]

History

Main page: Medicine:Discovery and development of proton pump inhibitors

Omeprazole was first made in 1979 by Swedish AB Hässle, part of Astra AB. It was the first of the proton pump inhibitors (PPI).[60][61] Astra AB, now AstraZeneca, launched it as an ulcer medicine under the name Losec in Sweden. It was first sold in the United States in 1989 under the brand name Losec. In 1990, at the request of the U.S. Food and Drug Administration, the brand name Losec was changed to Prilosec to avoid confusion with the diuretic Lasix (furosemide).[62] The new name led to confusion between omeprazole (Prilosec) and fluoxetine (Prozac), an antidepressant.[62]

Society and culture

Economics

When Prilosec's U.S. patent expired in April 2001, AstraZeneca introduced esomeprazole (Nexium) as a patented replacement drug.[63] Many companies introduced generics as AstraZeneca's patents expired worldwide, which are available under many brand names.

Omeprazole was a subject of a patent litigation in the U.S.[64] The invention involved application of two different coatings to a drug in pill form to ensure, that the omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coating was obvious, the patent was found valid, because the source of the problem was non-obvious and was discovered by the patentee.[65]

In September 2023, AstraZeneca announced it would pay $425 million to settle product liability litigations against Prilosec in the United States.[66]

Brand names

Brand names include Losec, Prilosec, Zegerid, Miracid, and Omez.[2][1]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 "Omeprazole". The American Society of Health-System Pharmacists. https://www.drugs.com/monograph/omeprazole.html. 
  2. ↑ 2.0 2.1 "Omeprazole international". 3 February 2020. https://www.drugs.com/international/omeprazole.html. 
  3. ↑ "Omeprazole Use During Pregnancy". 11 April 2019. https://www.drugs.com/pregnancy/omeprazole.html. 
  4. ↑ "Prilosec- omeprazole magnesium capsule, delayed release Prilosec- omeprazole magnesium granule, delayed release". 22 December 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a1b077e6-b070-43f2-a98e-380cc635419d. 
  5. ↑ "Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions". Clinical Drug Investigation 25 (6): 391–399. 2005. doi:10.2165/00044011-200525060-00004. PMID 17532679. http://www.medscape.com/viewarticle/508018. Retrieved 21 October 2018. 
  6. ↑ "Omeprazole MSDS". https://www.chemsrc.com/en/cas/73590-58-6_591579.html. 
  7. ↑ "[99 Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative"]. 28 June 2016. http://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/. 
  8. ↑ "Omeprazole 40 mg Powder for Solution for Infusion". 10 February 2016. https://www.medicines.org.uk/emc/medicine/25259. 
  9. ↑ "Zegerid- omeprazole and sodium bicarbonate powder, for suspension Zegerid- omeprazole and sodium bicarbonate capsule". 4 March 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd6868b9-5824-442b-8d65-4db29ecb70a4. 
  10. ↑ 10.0 10.1 "Zegerid OTC- omeprazole and sodium bicarbonate capsule, gelatin coated". 5 December 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ad1ca2b-3119-b8c2-e053-2a91aa0a2f77. 
  11. ↑ "Konvomep- omeprazole and sodium bicarbonate kit". 30 August 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=688ed6f1-d78a-4006-a682-57021cb38a3e. 
  12. ↑ 12.0 12.1 12.2 Davis's Drug Guide for Nurses (14th ed.). F.A. Davis Company. 2015. pp. 924–925. ISBN 978-0-8036-4085-6. OCLC 881473728. 
  13. ↑ "Drug Approval Package: Prilosec (Omeprazole) NDA# 019-810s38s50s5". 30 March 2001. https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/019810s38s50s56.cfm. 
  14. ↑ Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 445. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA445. Retrieved 29 June 2020. 
  15. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  16. ↑ "The Top 300 of 2021". https://clincalc.com/DrugStats/Top300Drugs.aspx. 
  17. ↑ "Omeprazole - Drug Usage Statistics, ClinCalc DrugStats Database". https://clincalc.com/DrugStats/Drugs/Omeprazole. 
  18. ↑ "Questions and Answers on Prilosec OTC (omeprazole)". 3 November 2018. https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole. 
  19. ↑ "Drug Approval Package: Prilosec (Omeprazole Magnesium) NDA #021229". https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-229_Prilosec.cfm. 
  20. ↑ "Proton pump inhibitors for eosinophilic oesophagitis". Current Opinion in Gastroenterology 29 (4): 416–420. July 2013. doi:10.1097/MOG.0b013e32835fb50e. PMID 23449027. 
  21. ↑ "Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication". Annals of Internal Medicine 147 (8): 553–562. October 2007. doi:10.7326/0003-4819-147-8-200710160-00008. PMID 17938394. 
  22. ↑ "Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report". Gut 56 (6): 772–781. June 2007. doi:10.1136/gut.2006.101634. PMID 17170018. 
  23. ↑ "Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders". Drugs 42 (1): 138–170. July 1991. doi:10.2165/00003495-199142010-00008. PMID 1718683. 
  24. ↑ "Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review". PLOS ONE 9 (6): e98400. 21 June 2014. doi:10.1371/journal.pone.0098400. PMID 24897375. Bibcode: 2014PLoSO...998400A. 
  25. ↑ "Long-term proton pump inhibitor therapy and risk of hip fracture". JAMA 296 (24): 2947–2953. December 2006. doi:10.1001/jama.296.24.2947. PMID 17190895. 
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  30. ↑ "Effect of proton pump inhibitors on vitamins and iron". The American Journal of Gastroenterology 104 (Suppl 2): S5–S9. March 2009. doi:10.1038/ajg.2009.45. PMID 19262546. 
  31. ↑ "Proton pump inhibitor-induced acute interstitial nephritis". British Journal of Clinical Pharmacology 64 (6): 819–823. December 2007. doi:10.1111/j.1365-2125.2007.02927.x. PMID 17635502. 
  32. ↑ "Proton pump inhibitor therapy and potential long-term harm". Current Opinion in Endocrinology, Diabetes, and Obesity 21 (1): 3–8. February 2014. doi:10.1097/med.0000000000000031. PMID 24310148. 
  33. ↑ "Proton pump inhibitors: Risks of long-term use". Journal of Gastroenterology and Hepatology 32 (7): 1295–1302. July 2017. doi:10.1111/jgh.13737. PMID 28092694. 
  34. ↑ "Long-Term Consequences of Chronic Proton Pump Inhibitor Use". US Pharmacist 38 (12): 38–42. 2013. https://www.uspharmacist.com/article/longterm-consequences-of-chronic-proton-pump-inhibitor-use. Retrieved 28 December 2020. 
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  36. ↑ "2014 Treatments for Acid-Peptic Diseases.". University of Minnesota Medical School Duluth. http://www.d.umn.edu/~jfitzake/Lectures/DMED/Antiulcer/Treatment/ReducePain/PPIs/PPIsSE.html. 
  37. ↑ "Proton Pump Inhibitor: Use in Adults". CMS Medicaid Integrity Program. http://www.cms.gov/Medicare-Medicaid-Coordination/Fraud-Prevention/Medicaid-Integrity-Education/Pharmacy-Education-Materials/Downloads/ppi-adult-factsheet.pdf. 
  38. ↑ "Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs". BMJ 345: e4388. July 2012. doi:10.1136/bmj.e4388. PMID 22782731. 
  39. ↑ "Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review". Heart 99 (8): 520–527. April 2013. doi:10.1136/heartjnl-2012-302371. PMID 22851683. 
  40. ↑ "Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions". Drug Metabolism and Disposition 41 (7): 1414–1424. July 2013. doi:10.1124/dmd.113.051722. PMID 23620487. 
  41. ↑ "The drug-drug interaction between proton pump inhibitors and clopidogrel". CMAJ 180 (7): 699–700. March 2009. doi:10.1503/cmaj.090251. PMID 19332744. 
  42. ↑ "Drug-drug interaction between clopidogrel and the proton pump inhibitors". The Annals of Pharmacotherapy 43 (7): 1266–1274. July 2009. doi:10.1345/aph.1M051. PMID 19470853. 
  43. ↑ Selective Serotonin Reuptake Inhibitors and CYP2D6 at eMedicine
  44. ↑ "Pharmacogenetics of oral anticoagulants". Pharmacogenetics 13 (5): 247–252. May 2003. doi:10.1097/00008571-200305000-00002. PMID 12724615. 
  45. ↑ 45.0 45.1 "Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors". Alimentary Pharmacology & Therapeutics 14 (8): 963–978. August 2000. doi:10.1046/j.1365-2036.2000.00788.x. PMID 10930890. 
  46. ↑ "Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein". Naunyn-Schmiedeberg's Archives of Pharmacology 364 (6): 551–557. December 2001. doi:10.1007/s00210-001-0489-7. PMID 11770010. 
  47. ↑ "Interactions between herbal medicines and prescribed drugs: an updated systematic review". Drugs 69 (13): 1777–1798. 2009. doi:10.2165/11317010-000000000-00000. PMID 19719333. 
  48. ↑ "Methotrexate". Martindale: The Complete Drug Reference. Pharmaceutical Press. 6 January 2014. http://www.medicinescomplete.com/mc/martindale/current/ms-9550-n.htm. 
  49. ↑ 49.0 49.1 "Clinical pharmacology of omeprazole". Clinical Pharmacokinetics 20 (1): 38–49. January 1991. doi:10.2165/00003088-199120010-00003. PMID 2029801. 
  50. ↑ 50.0 50.1 50.2 50.3 "Omeprazole". https://www.drugbank.ca/drugs/DB00338. 
  51. ↑ 51.0 51.1 "Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome". Drugs 32 (1): 15–47. July 1986. doi:10.2165/00003495-198632010-00002. PMID 3527658. 
  52. ↑ "Omeprazole package insert". India: Dr. Reddy's Laboratories Limited. June 2013. http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bced816b-6927-49fb-851f-f83a678dac97#nlm34090-1. 
  53. ↑ "Omeprazole: pharmacokinetics and metabolism in man". Scandinavian Journal of Gastroenterology. Supplement 166 (sup166): 33–40. 1 January 1989. doi:10.3109/00365528909091241. PMID 2690330. 
  54. ↑ "Guidelines for the diagnosis and management of gastroesophageal reflux disease". The American Journal of Gastroenterology 108 (3): 308–28; quiz 329. March 2013. doi:10.1038/ajg.2012.444. PMID 23419381. 
  55. ↑ "Omeprazole, in The Free Medical Dictionary". http://medical-dictionary.thefreedictionary.com/omeprazole. 
  56. ↑ "Omeprazole". Drugs.com. https://www.drugs.com/monograph/omeprazole.html. 
  57. ↑ "Nexium Prescribing Information". AstraZeneca Pharmaceuticals. http://www1.astrazeneca-us.com/pi/Nexium.pdf. 
  58. ↑ "Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies". Drug Metabolism and Pharmacokinetics 20 (3): 153–167. June 2005. doi:10.2133/dmpk.20.153. PMID 15988117. 
  59. ↑ Baselt RC, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1146–7. ISBN:978-0-9626523-7-0.
  60. ↑ "Trends in Drug Patenting - Case Studies: THE CASES: 5. OMEPRAZOLE". https://apps.who.int/medicinedocs/en/d/Js4915e/2.5.html. 
  61. ↑ "Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase". Nature 290 (5802): 159–161. March 1981. doi:10.1038/290159a0. PMID 6259537. Bibcode: 1981Natur.290..159F. 
  62. ↑ 62.0 62.1 "Making it easier to read prescriptions". FDA Consumer 29 (6): 25–27. July–August 1995. PMID 10143448. http://www.thebody.com/content/art13913.html. Retrieved 26 January 2011. 
  63. ↑ "Prilosec's Maker Switches Users To Nexium, Thwarting Generics". The Wall Street Journal. 6 June 2002. https://www.wsj.com/articles/SB1023326369679910840. 
  64. ↑ "AstraZeneca awarded damages in Prilosec patent litigation". AstraZeneca (Press release). 3 December 2013. Retrieved 4 October 2023.
  65. ↑ "IN RE OMEPRAZOLE PATENT LITIGATION, Court of Appeals, Federal Circuit 2011 - Google Scholar". https://scholar.google.com/scholar_case?case=12553883911671736992&q=+In+re+Omeprazole+Patent+Litigation&hl=en&as_sdt=40000003. 
  66. ↑ "AstraZeneca to pay $425 mln to settle Nexium, Prilosec litigation in US". Reuters. 3 October 2023. https://www.reuters.com/legal/astrazeneca-pay-425-mln-settle-nexium-prilosec-litigation-us-2023-10-03/. 

Further reading

External links



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