Medicine:ADAS-Cog
The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is a brief neuropsychological assessment used to assess the severity of cognitive symptoms of dementia. It is one of the most widely used cognitive scales in clinical trials[1] and is considered to be the “gold standard” for assessing antidementia treatments.[2] The ADAS-Cog is one half of the Alzheimer's Disease Assessment Scale (ADAS), which also contains a non-cognitive subscale (ADAS-Noncog), which includes 10 tasks which assess mood and behavioural changes which may occur in Alzheimer's disease and other forms of dementia.[2]
The ADAS-Cog consists of 11 questions:
- Word Recall Task
- Naming Objects and Fingers
- Following Commands
- Constructional Praxis
- Ideational Praxis
- Orientation
- Word Recognition Task
- Remembering Test Directions
- Spoken Language
- Comprehension
- Word-Finding Difficulty
Different versions
Since its original creation in 1980s there have been many alternate versions of the ADAS-Cog created for various reasons. A review found 31 modified versions of the ADAS-Cog,[2] these include:
- ADAS-Cog-IRT: Uses the standard 11 items from the ADAS-Cog but calculates the score based on item response theory. Using this method each question in the test is given a different value based on the difficulty, which is determined by how frequently it is answered correctly or incorrectly by a large reference group of participants.[3]
- ADAS-Cog Plus: Developed to be more responsive to the early stage deficits seen is mild cognitive impairment. It includes the standard ADAS-Cog with additional tests to assess executive function and day-to-day function.[4]
- VADAS-Cog: The VADAS-Cog is a variant the ADAS-Cog adapted to assess people with vascular dementia. It consists of the standard ADAS-Cog with additional measures for attention, working memory, executive function and verbal fluency.[5]
References
- ↑ Connor, D. J.; Sabbagh, M. N. (2008). "Administration and Scoring Variance on the ADAS-Cog". Journal of Alzheimer's Disease 15 (3): 461–464. doi:10.3233/JAD-2008-15312.
- ↑ 2.0 2.1 2.2 Kueper, J. K.; Speechley, M.; Montero-Odasso, M. (2018). "The Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog): Modifications and responsiveness in pre-dementia populations. A narrative review". Journal of Alzheimer's Disease 63 (2): 423–444. doi:10.3233/JAD-1709.
- ↑ Balsis, S. Unger; A. A., Benge; J. F.; Geraci, L.; Doody, R. S. (2015). "Gaining precision on the Alzheimer's Disease Assessment Scale-cognitive: A comparison of item response theory based scores and total scores.". Alzheimer's & Dementia 8: 288–293. doi:10.1016/j.jalz.2011.05.2409.
- ↑ Skinner, J.; Carvalho, J. O.; Guy, G. P.; Thames, A.; Zelinski, E.; Crane, P. K.; Gibbons, L. E. (2012). "The Alzheimer’s Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): An expansion of the ADAS-Cog to improve responsiveness in MCI". Brain Imaging and Behavior 6 (4): 489–501. doi:10.1007/s11682-012-9166-3.
- ↑ Ferris, S. H. (2005). "General measures of cognition". International Psychogeriatrics 15 (S1): 215–217. doi:10.1017/S1041610203009220.
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