Medicine:Acute beryllium poisoning
| Acute beryllium poisoning | |
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| Beryllium | |
| Specialty | Occupational medicine |
Acute beryllium poisoning is acute chemical pneumonitis resulting from the toxic effect of beryllium in its elemental form or in various chemical compounds, and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare.[1]
Signs and symptoms
Generally associated with exposure to beryllium levels at or above 100 μg/m3,[1] it produces severe cough, sore nose and throat, weight loss, labored breathing, anorexia, and increased fatigue.[2]:46
In addition to beryllium's toxicity when inhaled, when brought into contact with skin at relatively low doses, beryllium can cause local irritation and contact dermatitis, and contact with skin that has been scraped or cut may cause rashes or ulcers.[3] Beryllium dust or powder can irritate the eyes.[4]
Risk factors
Acute beryllium poisoning is an occupational disease.[1] Relevant occupations are those where beryllium is mined, processed or converted into metal alloys, or where machining of metals containing beryllium or recycling of scrap alloys occurs.[5]
Metallographic preparation equipment and laboratory work surfaces must be damp-wiped occasionally to inhibit buildup of particles. Cutting, grinding, and polishing procedures that generate dust or fumes must be handled within sufficiently vented coverings supplied with particulate filters.[6]
Diagnosis
Management
Therapy is supportive and includes removal from further beryllium exposure.[1] For very severe cases mechanical ventilation may be required.[7]
Prognosis
The signs and symptoms of acute beryllium pneumonitis usually resolve over several weeks to months, but may be fatal in 10 percent of cases,[1] and about 15–20% of cases may progress to chronic beryllium disease.[8]
Acute beryllium poisoning approximately doubles the risk of lung cancer.[9] The mechanism by which beryllium is carcinogenic is unclear, but may be due to ionic beryllium binding to nucleic acids; it is not mutagenic.[9]
Pathophysiology
History
Acute beryllium disease was first reported in Europe in 1933 and in the United States in 1943.[10]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 OSHA Beryllium Health Effects Page retrieved 29 March 2016
- ↑ Agency for Toxic Substances and Disease Registry. September 2002 Toxicological Profile: Beryllium. See also 2009 Addendum
- ↑ Agency for Toxic Substances and Disease Registry via the CDC. TOX FAQs: Beryllium Page last reviewed: 3 March 2011. Page last updated: 3 June 2015
- ↑ NIOSH International Chemical Safety Cards: Beryllium Page last reviewed: 22 July 2015. Page last updated: 1 July 2014
- ↑ ATSDR. ToxGuide for Beryllium September 2002
- ↑ Batich, Ray and James M. Marder. (1985) Beryllium In (Ed. 9), Metals Handbook: Metallography and Microstructures (pp. 389-391). Metals Park, Ohio: American Society for Metals.
- ↑ Newman, LS for the Merck Manual. Beryllium Disease Last full review/revision May 2014
- ↑ Hardy, HL (1965). "Beryllium poisoning--lessons in control of man-made disease". The New England Journal of Medicine 273 (22): 1188–99. doi:10.1056/NEJM196511252732205. PMID 5847559.
- ↑ 9.0 9.1 National Toxicology Program, Department of Health and Human Services. Report on Carcinogens, Thirteenth Edition Beryllium and Beryllium Compounds
- ↑ Lang, Leslie (June–July 1994). "Beryllium: A Chronic Problem". Environmental Health Perspectives 102 (6–7): 526–31. doi:10.1289/ehp.94102526. PMID 9679108.
This article incorporates public domain material from the United States Department of Health and Human Services website http://www.atsdr.cdc.gov/toxguides/toxguide-4.pdf.
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