Chemistry:Bombesin
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Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
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| Properties | |
| C71H110N24O18S | |
| Molar mass | 1619.85 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Bombesin is a 14-amino acid peptide[1] originally isolated from the skin of the European fire-bellied toad (Bombina bombina)[2] by Vittorio Erspamer et al. and named after its source.[3] It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.[4] It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.[5]
Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.[6]
Receptors
The anuran BB4 receptor homologue is termed frog BB4 (fBB4).[3] Iwabuchi et al. 2003 discovered a chicken (Gallus domesticus) receptor which is homologous to both the mammalian BB3 and fBB4 and so they named it chBRS-3.5.[3]
Effects
Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.[7]
See also
References
- ↑ "Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states". Current Opinion in Endocrinology, Diabetes and Obesity 15 (1): 58–64. February 2008. doi:10.1097/MED.0b013e3282f3709b. PMID 18185064.
- ↑
- Verkhratsky, Alexei; Nedergaard, Maiken (2018-01-01). "Physiology of Astroglia". Physiological Reviews (American Physiological Society) 98 (1): 239–389. doi:10.1152/physrev.00042.2016. ISSN 0031-9333. PMID 29351512.
- M., H. (1972). "Toxicon Reviews". Toxicon (International Society on Toxinology + Brazilian Society of Toxinology + North American Society of Toxinology (Elsevier)) 10 (2): 189. doi:10.1016/0041-0101(72)90248-6. ISSN 0041-0101. PMID 5544731.
- Daniel, Edwin E., ed (2019-08-15). Neuropeptide Function in the Gastrointestinal Tract. CRC Press. ISBN 978-0-429-28576-9. OCLC 1112671803.
- ↑ 3.0 3.1 3.2 Jensen, R. T.; Battey, J. F.; Spindel, E. R.; Benya, R. V. (2007-11-30). "International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States". Pharmacological Reviews (American Society for Pharmacology & Experimental Therapeutics (ASPET)) 60 (1): 1–42. doi:10.1124/pr.107.07108. ISSN 0031-6997. PMID 18055507. NIHMSID 45053.
- ↑ Weber HC (February 2009). "Regulation and signaling of human bombesin receptors and their biological effects". Current Opinion in Endocrinology, Diabetes and Obesity 16 (1): 66–71. doi:10.1097/med.0b013e32831cf5aa. PMID 19115523.
- ↑ "Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice". Annals of Medicine 32 (8): 519–29. November 2000. doi:10.3109/07853890008998831. PMID 11127929.
- ↑ "The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology 34 (12): 1224–9. December 1999. doi:10.1080/003655299750024742. PMID 10636070.
- ↑
- Moreno, Paola; Mantey, Samuel A.; Nakamura, Taichi; Nuche-Berenguer, Bernardo; Moody, Terry W.; Coy, David H.; Jensen, Robert T. (2001-09-06). "Insights into Bombesin receptors and ligands: Highlighting recent advances". Peptides (Elsevier) 72: 128–144. doi:10.1016/j.peptides.2015.04.026. PMID 25976083. NIHMSID 697823.
- Daniel, Edwin E., ed (2019-08-15). Neuropeptide Function in the Gastrointestinal Tract. CRC Press. ISBN 978-0-429-28576-9. OCLC 1112671803.
- Jensen, R. T.; Battey, J. F.; Spindel, E. R.; Benya, R. V. (2007-11-30). "International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States". Pharmacological Reviews (American Society for Pharmacology & Experimental Therapeutics (ASPET)) 60 (1): 1–42. doi:10.1124/pr.107.07108. ISSN 0031-6997. PMID 18055507. NIHMSID 45053.
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