Medicine:Fluorescein (medical use)
 Fluorescein drops being put in the eye before examination | |
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| Pronunciation | /ˈflʊərəsiːn/[1] |
| Trade names | Fluorescite, AK-Fluor, BioGlo, others |
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| Routes of administration | Eye drops, intravenous, by mouth |
| Drug class | Diagnostic agent |
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| Formula | C20H12O5 |
| Molar mass | 332.311 g·mol−1 |
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Fluorescein is used to help in the diagnosis of a number of eye problems.[3] When applied as a drop or within a strip of paper to the surface of the eye it is used to help detect eye injuries such as foreign bodies and corneal abrasions.[4][5] When given by mouth or injection into a vein it is used to help evaluate the blood vessels in the back of the eye during fluorescein angiography.[3][6]
When applied to the surface of the eye, side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type.[7][3] When used by mouth or injection, side effects may include headache, nausea, and a change to the color of the skin for a brief period of time.[3] Allergic reactions may rarely occur.[3] Fluorescein is a dye which is taken up by damaged cornea such that the area appears green under cobalt blue light.[3] There is also a version that comes premixed with lidocaine.[4][8]
Fluorescein was first made in 1871.[9] It is on the World Health Organization's List of Essential Medicines.[10]
Brand names
It is also sold as a combination drug with oxybuprocaine under the brand name Altafluor Benox.[11][12]
Other animals
It is also sometimes administered to pets in multi-pet environments to determine which pet needs behavioral modification.[citation needed]
References
- ↑ "Fluorescein | Definition of Fluorescein by Oxford Dictionary on Lexico.com also meaning of Fluorescein". https://www.lexico.com/definition/fluorescein.
- ↑ "Fluorescein sodium 100 mg/ml, solution for injection - Summary of Product Characteristics (SmPC)". 16 January 2018. https://www.medicines.org.uk/emc/product/8829/smpc.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Duvall, Brian; Kershner, Robert M. (2006) (in en). Ophthalmic Medications and Pharmacology. 17. SLACK Incorporated. 151–8. ISBN 9781556427503. https://books.google.com/books?id=YsYi6dzIKKUC&pg=PA29.
- ↑ 4.0 4.1 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 769, 772. ISBN 9780857111562.
- ↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 416. ISBN 9781284057560.
- ↑ "Anatera 100mg/ml solution for injection - Summary of Product Characteristics (SmPC)". 10 February 2020. https://www.medicines.org.uk/emc/product/9696/smpc.
- ↑ WHO Model Formulary 2008. World Health Organization. 2009. p. 314. ISBN 9789241547659.
- ↑ "Minims Lidocaine & Fluorescein Summary of Product Characteristics (SmPC) - (emc)". 23 October 2017. https://www.medicines.org.uk/emc/product/154/smpc.
- ↑ Bartlett, Jimmy D.; Jaanus, Siret D. (2008) (in en). Clinical Ocular Pharmacology. Elsevier Health Sciences. p. 283. ISBN 978-0750675765. https://books.google.com/books?id=Eybg7fbs65MC&pg=PA283.
- ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ↑ "Drug Approval Package: Altafluor Benox (fluorescein sodium and benoxinate hydrochloride ophthalmic solution)". 9 April 2018. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208582Orig1s000TOC.cfm.
- ↑ "Altafluor- fluorescein sodium and benoxinate hydrochloride solution". 4 December 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54017304-e680-4129-b52a-69cb9810af76.
External links
- "Fluorescein". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/fluorescein.
- "Fluorescein sodium". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/fluorescein%20sodium.
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