Medicine:Heerfordt syndrome
| Heerfordt syndrome | |
|---|---|
| Other names | Uveoparotid fever,[1] Heerfordt–Mylius syndrome, Heerfordt–Waldenström syndrome, and Waldenström's uveoparotitis[2] |
Heerfordt syndrome is a rare manifestation of sarcoidosis. The symptoms include inflammation of the eye (uveitis), swelling of the parotid gland, chronic fever, and in some cases, palsy of the facial nerves.[1]
Causes
The exact cause of Heerfordt syndrome has not yet been definitively determined. Of those patients who have been diagnosed with Heerfordt syndrome, 15% have a close relative who also has the syndrome. One possible explanation is that the syndrome results from a combination of an environmental agent and a hereditary predisposition. Mycobacterium and Propionibacteria species have both been suggested as the environmental agent, though the evidence for this is inconclusive.[1]
Diagnosis
In patients that have already been diagnosed with sarcoidosis, Heerfordt syndrome can be inferred from the major symptoms of the syndrome, which include parotitis, fever, facial nerve palsy and anterior uveitis. In cases of parotitis, ultrasound-guided biopsy is used to exclude the possibility of lymphoma.[3] There are many possible causes of facial nerve palsy, including Lyme disease, HIV, Melkersson–Rosenthal syndrome, schwannoma, and Bell's palsy. Heerfordt syndrome exhibits spontaneous remission.[citation needed]
Treatment
Treatments for sarcoidosis include corticosteroids and immunosuppressive drugs.[1]
Prevalence
In the United States, sarcoidosis has a prevalence of approximately 10 cases per 100,000 whites and 36 cases per 100,000 blacks.[4] Heerfordt syndrome is present in 4.1 to 5.6% of those with sarcoidosis.[5]
History
The condition was first described in 1909 by Danish ophthalmologist Christian Frederick Heerfordt, for whom the syndrome is now named.[6] It was originally attributed to mumps, but after further studies by Swedish doctor Jan G. Waldenström in 1937, it was classified as a distinct manifestation of sarcoidosis.[2][7]
See also
- Darier–Roussy disease
- Sarcoidosis
- List of cutaneous conditions
Notes
- Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
References
- ↑ 1.0 1.1 1.2 1.3 Evanchan, Jason; Barreiro, Timothy J.; Gemmel, David (May 2010). "Uveitis, salivary gland swelling, and facial nerve palsy in a febrile woman". Journal of the American Academy of Physician Assistants 23 (5): 46–50. doi:10.1097/01720610-201005000-00012. PMID 20480871.
- ↑ 2.0 2.1 synd/3546 at Who Named It?
- ↑ Fischer, T. (January 2002). "Diagnosis of Heerfordt's syndrome by state-of-the-art ultrasound in combination with parotid biopsy: a case report.". European Radiology 12 (1): 134–7. doi:10.1007/s003300100879. PMID 11868089.
- ↑ Iannuzzi, Michael C.; Rybicki, Benjamin A.; Teirstein, Alvin S. (22 November 2007). "Sarcoidosis". New England Journal of Medicine 357 (21): 2153–65. doi:10.1056/NEJMra071714. PMID 18032765.
- ↑ "Radiculopathy in patients with Heerfordt's syndrome: two case presentations and review of the literature". Brain and Nerve 65 (8): 989–92. August 2013. PMID 23917502.
- ↑ Heerfordt C. F. (1909). "Über eine "Febris uveo-parotidea subchronica" an der Glandula parotis und der Uvea des Auges lokalisiert und häufug mit Paresen cerebrospinaler Nerven kompliziert". Albrecht von Graefes Archiv für Ophthalmologie 70 (2): 254–273. doi:10.1007/bf02008817. https://zenodo.org/record/1428374.
- ↑ Waldenström, J. G. (1937). "Some observations on uveoparotitis and allied conditions with special reference to the symptoms from the nervous system". Acta Medica Scandinavica 91 (1–2): 53–68. doi:10.1111/j.0954-6820.1937.tb16029.x.
External links
| Classification |
|---|
 |  |
