Medicine:Pemberton's sign
Pemberton's sign | |
---|---|
Differential diagnosis | superior vena cava syndrome |
Pemberton's sign was named after Hugh Pemberton, who characterized it in 1946.[1]
The Pemberton maneuver is a physical examination tool used to demonstrate the presence of latent pressure in the thoracic inlet.[2] The maneuver is achieved by having the patient elevate both arms (usually 180 degrees anterior flexion at the shoulder) until the forearms touch the sides of the face. A positive Pemberton's sign is marked by the presence of facial congestion and cyanosis, as well as respiratory distress after approximately one minute.[3]
Causes
A positive Pemberton's sign is indicative of superior vena cava syndrome (SVC), commonly the result of a mass in the mediastinum. Although the sign is most commonly described in patients with substernal goiters where the goiter “corks off” the thoracic inlet,[4] the maneuver is potentially useful in any patient with adenopathy, tumor, or fibrosis involving the mediastinum. SVC syndrome has been observed as a result of diffuse mediastinal lymphadenopathy of various pathologies such as cystic fibrosis [5] and Castleman’s disease.[6] Park et al. reported enlarged cervical lymph nodes associated with hemophagocytic lymphohistiocytosis as the cause of internal jugular vein compression, which presented clinically similar to SVC syndrome.[7]
References
- ↑ Pemberton, HS (1946). "Sign of submerged goitre". Lancet 248 (6423): 509. doi:10.1016/s0140-6736(46)91790-4.
- ↑ Wallace, C; Siminoski K (1996). "The Pemberton sign". Ann Intern Med 125 (7): 568–569. doi:10.7326/0003-4819-125-7-199610010-00006. PMID 8815756.
- ↑ Pemberton, HS (1946). "Sign of submerged goitre". Lancet 248 (6423): 509. doi:10.1016/s0140-6736(46)91790-4.
- ↑ Basaria, S; Salvatori R (2004). "Pemberton's sign". New England Journal of Medicine 350 (13): 1338. doi:10.1056/nejmicm990287. PMID 15044645.
- ↑ Chow, J et al. (1997). "Superior vena cava obstruction secondary to mediastinal lymphadenopathy in a patient with cystic fibrosis". Chest 112 (5): 1438–1441. doi:10.1378/chest.112.5.1438. PMID 9367491.
- ↑ Tekinbas, C et al. (2008). "Giant mass due to Castleman's disease causing superior vena cava syndrome.". Thorac Cardiovasc Surg 56 (5): 303–305. doi:10.1055/s-2008-1038408. PMID 18615381.
- ↑ Park, M et al. (2012). "Hemophagocytic lymphohistiocytosis can mimic the superior vena cava syndrome". J Pediatr Hematol Oncol 34 (4): 152–154. doi:10.1097/MPH.0b013e3182422a20. PMID 22395213.
Further reading
- Abu-Shama Y and Cuny T. Pemberton’s Sign in a Patient with a Goiter. N Engl J Med. 2018;378:e31. doi:10.1056/NEJMicm1712263. A short case illustrating Pemberton's sign, with images and a video.
![]() | Original source: https://en.wikipedia.org/wiki/Pemberton's sign.
Read more |