Biology:HslU—HslV peptidase
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HslU—HslV peptidase | |||||||||
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![]() Heat shock peptidase dodekamer, E.Coli | |||||||||
Identifiers | |||||||||
EC number | 3.4.25.2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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HslU—HslV peptidase (EC 3.4.25.2, HslUV, HslV-HslU, HslV peptidase, ATP-dependent HslV-HslU proteinase, caseinolytic protease X, caseinolytic proteinase X, ClpXP ATP-dependent protease, ClpXP protease, ClpXP serine proteinase, Escherichia coli ClpXP serine proteinase, HslUV protease, HslUV proteinase, HslVU protease, HslVU proteinase, protease HslVU, proteinase HslUV) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- ATP-dependent cleavage of peptide bonds with broad specificity.
This enzyme belongs to the peptidase family T1.
References
- ↑ "Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects". Acta Crystallographica Section D 61 (Pt 7): 932–41. July 2005. doi:10.1107/s0907444905009546. PMID 15983416.
- ↑ "Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli". FEBS Letters 553 (3): 351–4. October 2003. doi:10.1016/s0014-5793(03)01044-5. PMID 14572649.
- ↑ "Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)". Proceedings of the National Academy of Sciences of the United States of America 99 (11): 7396–401. May 2002. doi:10.1073/pnas.102188799. PMID 12032294.
- ↑ "Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli". The Journal of Biological Chemistry 271 (24): 14035–40. June 1996. doi:10.1074/jbc.271.24.14035. PMID 8662828.
- ↑ "ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli". Biochemical and Biophysical Research Communications 238 (2): 581–5. September 1997. doi:10.1006/bbrc.1997.7341. PMID 9299555.
- ↑ "Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of sigma32 and abnormal proteins in Escherichia coli". Journal of Bacteriology 179 (23): 7219–25. December 1997. PMID 9393683.
- ↑ "Nucleotide-dependent substrate recognition by the AAA+ HslUV protease". Nature Structural & Molecular Biology 12 (3): 245–51. March 2005. doi:10.1038/nsmb898. PMID 15696175.
External links
- HslU---HslV+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)