Biology:Carboxypeptidase B

From HandWiki
Short description: Class of enzymes
carboxypeptidase B1 (tissue)
Identifiers
SymbolCPB1
NCBI gene1360
HGNC2299
OMIM114852
RefSeqNM_001871
UniProtP15086
Other data
EC number3.4.17.2
LocusChr. 3 q24
carboxypeptidase B2 (plasma)
Identifiers
SymbolCPB2
NCBI gene1361
HGNC2300
OMIM603101
RefSeqNM_016413
UniProtQ96IY4
Other data
LocusChr. 13 q14.11
carboxypeptidase B
Identifiers
EC number3.4.17.2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially cleaves off basic amino acids arginine and lysine from the C-terminus of a peptide.[1][2][3][4] This enzyme is secreted by the pancreas, and it travels to the small intestine, where it aids in protein digestion. Plasma carboxypeptidase B (carboxypeptidase B2) is responsible for converting the C5a protein into C5a des-Arg, with one less amino acid.

References

  1. Carboxypeptidase B (porcine pancreas). Methods Enzymol.. 19. 1970. pp. 504–508. doi:10.1016/0076-6879(70)19036-7. ISBN 9780121818814. 
  2. "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion". Biochimica et Biophysica Acta (BBA) - Enzymology 452 (2): 468–81. December 1976. doi:10.1016/0005-2744(76)90197-2. PMID 1009123. 
  3. "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis". Clinica Chimica Acta; International Journal of Clinical Chemistry 97 (1): 39–43. September 1979. doi:10.1016/0009-8981(79)90023-8. PMID 40714. 
  4. "Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?". Life Sciences 31 (16–17): 1793–6. 1982. doi:10.1016/0024-3205(82)90212-0. PMID 6130442. 

External links