Chemistry:1,3-Benzodioxole
From HandWiki
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| Names | |||
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| Preferred IUPAC name
2H-1,3-Benzodioxole | |||
| Other names
1,3-Benzodioxole
Benzo[d][1,3]dioxole 1,2-[Methylenebis(oxy)]benzene 1,2-Methylenedioxybenzene | |||
| Identifiers | |||
3D model (JSmol)
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| 115506 | |||
| ChEBI | |||
| ChemSpider | |||
| EC Number |
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| MeSH | 1,3-Benzodioxole | ||
PubChem CID
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| RTECS number |
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| UNII | |||
| UN number | 1993 | ||
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| Properties | |||
| C7H6O2 | |||
| Molar mass | 122.123 g·mol−1 | ||
| Density | 1.064 g cm−3 | ||
| Boiling point | 172–173 °C (342–343 °F; 445–446 K) | ||
| log P | 2.08 | ||
| Vapor pressure | 1.6 kPa | ||
| Thermochemistry | |||
Std enthalpy of
combustion (ΔcH⦵298) |
-3.428 MJ mol−1 | ||
| Hazards | |||
| GHS pictograms | 
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| GHS Signal word | WARNING | ||
| H302, H332 | |||
| NFPA 704 (fire diamond) | |||
| Flash point | 61 °C (142 °F; 334 K) | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
 verify (what is   ?)
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| Infobox references | |||
(1,3)dioxole_200.svg)
1,3-Benzodioxole (1,2-methylenedioxybenzene) is an organic compound with the formula C6H4O2CH2. The compound is classified as benzene derivative and a heterocyclic compound containing the methylenedioxy functional group. It is a colorless liquid.
Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.[1]
Preparation
1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.[2][3]
See also
References
- ↑ Murray, M., "Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation", Curr. Drug Metab. 2000, volume 1, 67-84. doi:10.2174/1389200003339270
- ↑ Bonthrone, W.; Cornforth, J. (1969). "The methylenation of catechols". Journal of the Chemical Society (9): 1202–1204. doi:10.1039/J39690001202. http://pubs.rsc.org/en/content/articlelanding/1969/J3/j39690001202. Retrieved 28 December 2013.
- ↑ Fujita, Harushige; Yamashita; Masataro (1973). "The Methylenation of Several Allylbenzene-1,2-diol Derivatives in Aprotic Polar Solvents". Bulletin of the Chemical Society of Japan 46 (11): 3553–3554. doi:10.1246/bcsj.46.3553. https://www.jstage.jst.go.jp/article/bcsj1926/46/11/46_11_3553/_article. Retrieved 27 December 2013.
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