Biology:SCG5
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Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[1][2][3] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.[4][5] It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects.[6] It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2[7] and then renamed Seven B Two (gene name sbt-1). There is a Pfam entry for this protein: Secretogranin_V (PF05281).
References
- ↑ "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic Molecular Pathology 3 (1): 38–45. March 1994. doi:10.1097/00019606-199403010-00007. PMID 8162254.
- ↑ "The chromogranin-secretogranin family". The New England Journal of Medicine 348 (12): 1134–49. March 2003. doi:10.1056/NEJMra021405. PMID 12646671.
- ↑ "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters 234 (1): 160–4. July 1988. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
- ↑ "Entrez Gene: SCG5 secretogranin V (7B2 protein)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6447.
- ↑ "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal 357 (Pt 2): 329–42. July 2001. doi:10.1042/0264-6021:3570329. PMID 11439082. PMC 1221959. http://www.biochemj.org/bj/357/0329/bj3570329.htm.
- ↑ "Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion". The Journal of Biological Chemistry 275 (23): 17886–93. June 2000. doi:10.1074/jbc.M000032200. PMID 10749852.
- ↑ "Transplacental in vivo/in vitro mutagenicity of AF-2, a nitrofuran, in golden hamster cells [proceedings]". Mutation Research 38 (5): 338. October 1976. doi:10.1016/0165-1161(76)90163-1. PMID 972625.
Further reading
- "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal 357 (Pt 2): 329–42. July 2001. doi:10.1042/0264-6021:3570329. PMID 11439082.
- "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man". Biochemical and Biophysical Research Communications 174 (1): 156–62. January 1991. doi:10.1016/0006-291X(91)90499-W. PMID 1989596.
- "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization". Cytogenetics and Cell Genetics 50 (2–3): 158–60. 1989. doi:10.1159/000132749. PMID 2776483.
- "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors". Endocrinology 123 (2): 874–84. August 1988. doi:10.1210/endo-123-2-874. PMID 2840270.
- "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters 234 (1): 160–4. July 1988. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
- "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein". DNA 7 (10): 713–9. December 1988. doi:10.1089/dna.1988.7.713. PMID 3234177.
- "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma". Endocrinology 123 (2): 866–73. August 1988. doi:10.1210/endo-123-2-866. PMID 3293987.
- "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Research 380 (2): 349–56. August 1986. doi:10.1016/0006-8993(86)90233-7. PMID 3530373.
- "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus". Archives of Biochemistry and Biophysics 225 (2): 525–34. September 1983. doi:10.1016/0003-9861(83)90063-2. PMID 6625600.
- "7B2 is a specific intracellular binding protein of the prohormone convertase PC2". Journal of Neurochemistry 64 (5): 2303–11. May 1995. doi:10.1046/j.1471-4159.1995.64052303.x. PMID 7722516.
- "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway". Cell 78 (2): 263–73. July 1994. doi:10.1016/0092-8674(94)90296-8. PMID 7913882.
- "Structural organization of the gene encoding the neuroendocrine chaperone 7B2". European Journal of Biochemistry 236 (1): 60–7. February 1996. doi:10.1111/j.1432-1033.1996.00060.x. PMID 8617287.
- "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators". Oncogene 23 (8): 1575–85. February 2004. doi:10.1038/sj.onc.1207277. PMID 14767469.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. May 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "The neuroendocrine protein 7B2 is intrinsically disordered". Biochemistry 51 (38): 7456–64. September 2012. doi:10.1021/bi300871k. PMID 22947085.
- "The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins". The Journal of Biological Chemistry 288 (2): 1114–24. January 2013. doi:10.1074/jbc.M112.417071. PMID 23172224.
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