Biology:Olfactory marker protein

From HandWiki
olfactory marker protein
Identifiers
SymbolOMP
NCBI gene4975
HGNC8136
OMIM164340
RefSeqNM_006189
UniProtP47874
Other data
LocusChr. 11 q14-q21
Olfactory marker protein
PDB 1jyt EBI.jpg
solution structure of olfactory marker protein from rat
Identifiers
SymbolOlfactory_mark
PfamPF06554
InterProIPR009103
SCOP21jyt / SCOPe / SUPFAM

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein–protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2]

External links

References

  1. "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. June 2002. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873. 
  2. "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. June 2002. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872. 
This article incorporates text from the public domain Pfam and InterPro: IPR009103