Biology:GPS2 (gene)
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G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.[1][2]
Function
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[2]
Interactions
GPS2 (gene) has been shown to interact with:
References
- ↑ "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Molecular and Cellular Biology 16 (12): 6698–706. Dec 1996. doi:10.1128/mcb.16.12.6698. PMID 8943324.
- ↑ 2.0 2.1 "Entrez Gene: GPS2 G protein pathway suppressor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514.
- ↑ "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry 279 (32): 33727–41. Aug 2004. doi:10.1074/jbc.M401708200. PMID 15159402.
- ↑ "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". Journal of Virology 74 (13): 5872–9. Jul 2000. doi:10.1128/jvi.74.13.5872-5879.2000. PMID 10846067.
- ↑ 6.0 6.1 6.2 "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell 9 (3): 611–23. Mar 2002. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
- ↑ "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. Sep 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- ↑ "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal 22 (6): 1336–46. Mar 2003. doi:10.1093/emboj/cdg120. PMID 12628926.
- ↑ "AMF1 (GPS2) modulates p53 transactivation". Molecular and Cellular Biology 21 (17): 5913–24. Sep 2001. doi:10.1128/mcb.21.17.5913-5924.2001. PMID 11486030.
Further reading
- "A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha". The Journal of Biological Chemistry 272 (41): 25816–23. Oct 1997. doi:10.1074/jbc.272.41.25816. PMID 9325311.
- "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". Journal of Virology 74 (13): 5872–9. Jul 2000. doi:10.1128/JVI.74.13.5872-5879.2000. PMID 10846067.
- "Gps2, a protein partner for human papillomavirus E6 proteins". Journal of Virology 75 (1): 151–60. Jan 2001. doi:10.1128/JVI.75.1.151-160.2001. PMID 11119584.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 8 (2): 85–95. Apr 2001. doi:10.1093/dnares/8.2.85. PMID 11347906.
- "AMF1 (GPS2) modulates p53 transactivation". Molecular and Cellular Biology 21 (17): 5913–24. Sep 2001. doi:10.1128/MCB.21.17.5913-5924.2001. PMID 11486030.
- "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell 9 (3): 611–23. Mar 2002. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
- "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal 22 (6): 1336–46. Mar 2003. doi:10.1093/emboj/cdg120. PMID 12628926.
- "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. Sep 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry 279 (32): 33727–41. Aug 2004. doi:10.1074/jbc.M401708200. PMID 15159402.
- "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment". DNA Repair 5 (1): 32–42. Jan 2006. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis". Proceedings of the National Academy of Sciences of the United States of America 104 (40): 15665–70. Oct 2007. doi:10.1073/pnas.0706736104. PMID 17895379.
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