Biology:Cysteine—tRNA ligase
Cysteine—tRNA ligase | |||||||||
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Identifiers | |||||||||
EC number | 6.1.1.16 | ||||||||
CAS number | 37318-56-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a cysteine—tRNA ligase (EC 6.1.1.16) is an enzyme that catalyzes the chemical reaction
- ATP + L-cysteine + tRNACys [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + L-cysteinyl-tRNACys
The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1LI5, 1LI7, and 1U0B.
References
- "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coliI". Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects 91 (4): 541–8. December 1964. doi:10.1016/0926-6550(64)90001-5. PMID 14262440.
![]() | Original source: https://en.wikipedia.org/wiki/Cysteine—tRNA ligase.
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