Biology:Propionate—CoA ligase
From HandWiki
| Propionate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.2.1.17 | ||||||||
| CAS number | 55326-49-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a propionate—CoA ligase (EC 6.2.1.17) is an enzyme that catalyzes the chemical reaction
- ATP + propanoate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + propanoyl-CoA
The 3 substrates of this enzyme are ATP, propanoate, and CoA, whereas its 3 products are AMP, diphosphate, and propanoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is propanoate:CoA ligase (AMP-forming). This enzyme is also called propionyl-CoA synthetase. This enzyme participates in propanoate metabolism.
References
- "Regulation of volatile fatty acid uptake by mitochondrial acyl CoA synthetases of bovine liver". Journal of Dairy Science 64 (12): 2324–35. 1981. doi:10.3168/jds.S0022-0302(81)82854-8. PMID 7341659.
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