Biology:3-hydroxybutyryl-CoA dehydratase
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Short description: Class of enzymes
| 3-hydroxybutyryl-CoA dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-hydroxybutyryl-CoA dehydratase homotrimer, Myxococcus xanthus | |||||||||
| Identifiers | |||||||||
| EC number | 4.2.1.55 | ||||||||
| CAS number | 37290-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) catalyzes the chemical reaction
- (3R)-3-hydroxybutanoyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] crotonoyl-CoA + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming). Other names in common use include D-3-hydroxybutyryl coenzyme A dehydratase, D-3-hydroxybutyryl-CoA dehydratase, enoyl coenzyme A hydrase (D), and (3R)-3-hydroxybutanoyl-CoA hydro-lyase. This enzyme participates in butanoate metabolism.
References
- "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(−)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum". Biochemistry 8 (7): 2748–55. 1969. doi:10.1021/bi00835a009. PMID 5808333.
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