Biology:5-epiaristolochene synthase
From HandWiki
Short description: Enzyme
| 5-epiaristolochene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
5-Epiaristolochene synthase (EC 4.2.3.61, 5-epi-aristolochene synthase, tobacco epiaristolochene synthase, farnesyl pyrophosphate cyclase, EAS, TEAS) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-5-epiaristolochene-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] (+)-5-epiaristolochene + diphosphate
Initial cyclization gives (+)-germacrene A in an enzyme-bound form.
References
- ↑ "Expression of a plant sesquiterpene cyclase gene in Escherichia coli". Archives of Biochemistry and Biophysics 315 (2): 527–32. December 1994. doi:10.1006/abbi.1994.1533. PMID 7986100.
- ↑ "Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase". Science 277 (5333): 1815–20. September 1997. doi:10.1126/science.277.5333.1815. PMID 9295271. https://pdfs.semanticscholar.org/0a1f/ad54ddcd30fa2b82c2966bcbe39b8d618377.pdf.
- ↑ "Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in UV-challenged leaves of Capsicum annuum". Plant & Cell Physiology 39 (9): 899–904. September 1998. doi:10.1093/oxfordjournals.pcp.a029452. PMID 9816674.
- ↑ "Demonstration of germacrene A as an intermediate in 5-epi-aristolochene synthase catalysis". J. Am. Chem. Soc. 122 (9): 1861–1866. 2000. doi:10.1021/ja993584h.
- ↑ "Gene expression of 5-epi-aristolochene synthase and formation of capsidiol in roots of Nicotiana attenuata and N. sylvestris". Phytochemistry 60 (2): 109–16. May 2002. doi:10.1016/s0031-9422(02)00080-8. PMID 12009313.
- ↑ "Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase". Archives of Biochemistry and Biophysics 448 (1–2): 73–82. April 2006. doi:10.1016/j.abb.2005.10.028. PMID 16375847.
External links
- 5-epiaristolochene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
