Biology:SPR domain
| Sprouty | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | SPR | ||||||||
| Pfam | PF05210 | ||||||||
| InterPro | IPR007875 | ||||||||
| |||||||||
In molecular biology the SPR domain is a protein domain found in the Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases.[1][2] These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain.[2][3][4][5] It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential.[2][6] It also mediates homodimer formation of these proteins.[3][6]
The SPR domain can occur in association with the WH1 domain (see InterPro: IPR000697) (located in the N-terminus) in the Spred proteins.
Examples
Human genes encoding protein containing the SPR domain include:
References
- ↑ "Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis". Mechanisms of Development 109 (2): 367–70. December 2001. doi:10.1016/S0925-4773(01)00526-3. PMID 11731251.
- ↑ 2.0 2.1 2.2 "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes". Molecular and Cellular Biology 22 (22): 7953–66. November 2002. doi:10.1128/MCB.22.22.7953-7966.2002. PMID 12391162.
- ↑ 3.0 3.1 "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". The Biochemical Journal 388 (Pt 2): 445–54. June 2005. doi:10.1042/BJ20041284. PMID 15683364.
- ↑ "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". The Journal of Biological Chemistry 275 (42): 32837–45. October 2000. doi:10.1074/jbc.M002156200. PMID 10887178.
- ↑ "Spred is a Sprouty-related suppressor of Ras signalling". Nature 412 (6847): 647–51. August 2001. doi:10.1038/35088082. PMID 11493923. Bibcode: 2001Natur.412..647W.
- ↑ 6.0 6.1 "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology 4 (11): 850–8. November 2002. doi:10.1038/ncb867. PMID 12402043.
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