Biology:(cytochrome c)-lysine N-methyltransferase
| [cytochrome c]-lysine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.59 | ||||||||
| CAS number | 82047-78-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a [cytochrome c]-lysine N-methyltransferase (EC 2.1.1.59) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + [cytochrome c]-L-lysine [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
Thus, the two substrates of this enzyme are S-adenosyl methionine and cytochrome c-L-lysine, whereas its two products are S-adenosylhomocysteine and cytochrome c-N6-methyl-L-lysine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase. Other names in common use include cytochrome c (lysine) methyltransferase, cytochrome c methyltransferase, cytochrome c-specific protein methylase III, cytochrome c-specific protein-lysine methyltransferase, S-adenosyl-L-methionine:[cytochrome c]-L-lysine, and 6-N-methyltransferase. This enzyme participates in lysine degradation.
References
- "Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements". J. Biol. Chem. 253 (5): 1427–35. 1978. PMID 203592.
- "Cytochrome c-specific protein methylase III from Neurospora crassa". Biochem. J. 165 (1): 11–8. 1977. PMID 196592.
- "A cytochrome c methyltransferase from Crithidia oncopelti". Biochem. J. 201 (2): 329–38. 1982. PMID 6282265.
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