Biology:Petromyzonol sulfotransferase
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Short description: Class of enzymes
| Petromyzonol sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.31 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a petromyzonol sulfotransferase (EC 2.8.2.31) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol, whereas its two products are adenosine 3',5'-bisphosphate and 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-te trol sulfotransferase. This enzyme is also called PZ-SULT.
References
- "Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver". J. Lipid Res. 45 (3): 486–95. 2004. doi:10.1194/jlr.M300346-JLR200. PMID 14657197.
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