Biology:Aryl sulfotransferase
aryl sulfotransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.8.2.1 | ||||||||
CAS number | 9026-09-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Arylsulfotransferase | |||||||||
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Identifiers | |||||||||
Symbol | Arylsulfotransferase | ||||||||
Pfam | PF05935 | ||||||||
InterPro | IPR010262 | ||||||||
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An aryl sulfotransferase (EC 2.8.2.1) is an enzyme that transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.[1]
- 3'-phosphoadenylyl sulfate + a phenol [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + an aryl sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenol, whereas its two products are adenosine 3',5'-bisphosphate and aryl sulfate.
These enzymes are transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:phenol sulfotransferase. Other names in common use include phenol sulfotransferase, sulfokinase, 1-naphthol phenol sulfotransferase, 2-naphtholsulfotransferase, 4-nitrocatechol sulfokinase, arylsulfotransferase, dopamine sulfotransferase, p-nitrophenol sulfotransferase, phenol sulfokinase, ritodrine sulfotransferase, and PST. This enzyme participates in sulfur metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1LS6, 1Z28, 1Z29, 2A3R, and 2D06.
References
- ↑ "Cloning and sequencing of the Klebsiella K-36 astA gene, encoding an arylsulfate sulfotransferase". Microbiol. Immunol. 40 (8): 531–537. 1996. doi:10.1111/j.1348-0421.1996.tb01105.x. PMID 8887346.
Further reading
![]() | Original source: https://en.wikipedia.org/wiki/Aryl sulfotransferase.
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