Biology:Indole-3-glycerol-phosphate lyase
| Indole-3-glycerol-phosphate lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme indole-3-glycerol-phosphate lyase (EC 4.1.2.8) catalyzes the chemical reaction
- (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] indole + D-glyceraldehyde 3-phosphate
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming). Other names in common use include tryptophan synthase alpha, TSA, indoleglycerolphosphate aldolase, indole glycerol phosphate hydrolase, indole synthase, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase, indole-3-glycerol phosphate lyase, IGL, BX1, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in benzoxazinone biosynthesis.
References
- YANOFSKY C (1956). "The enzymatic conversion of anthranilic acid to indole". J. Biol. Chem. 223 (1): 171–84. doi:10.1016/S0021-9258(18)65126-9. PMID 13376586.
- SP, Simcox K; Gierl A (1997). "Analysis of a chemical plant defense mechanism in grasses". Science 277 (5326): 696–699. doi:10.1126/science.277.5326.696. PMID 9235894.
- "An herbivore elicitor activates the gene for indole emission in maize". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14801–6. 2000. doi:10.1073/pnas.260499897. PMID 11106389. Bibcode: 2000PNAS...9714801F.
- "A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 13345–50. 1997. doi:10.1073/pnas.94.24.13345. PMID 9371848. Bibcode: 1997PNAS...9413345M.
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