Biology:Low-specificity L-threonine aldolase
From HandWiki
| Low-specificity L-threonine aldolase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.1.2.48 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Low-specificity L-threonine aldolase (EC 4.1.2.48, LtaE) is an enzyme with systematic name L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) L-threonine [math]\displaystyle{ \rightleftharpoons }[/math] glycine + acetaldehyde
- (2) L-allothreonine [math]\displaystyle{ \rightleftharpoons }[/math] glycine + acetaldehyde
This enzyme requires pyridoxal phosphate.
References
- ↑ "Crystalline threonine aldolase from Candida humicola". Biochemical and Biophysical Research Communications 39 (1): 53–8. April 1970. doi:10.1016/0006-291x(70)90756-4. PMID 5438301.
- ↑ "Threonine aldolase from Candida humicola. II. Purification, crystallization and properties". Biochimica et Biophysica Acta (BBA) - Enzymology 258 (3): 779–90. March 1972. doi:10.1016/0005-2744(72)90179-9. PMID 5017702.
- ↑ "The GLY1 gene of Saccharomyces cerevisiae encodes a low-specific L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine--expression of the gene in Escherichia coli and purification and characterization of the enzyme". European Journal of Biochemistry 245 (2): 289–93. April 1997. doi:10.1111/j.1432-1033.1997.00289.x. PMID 9151955.
- ↑ "Gene cloning, biochemical characterization and physiological role of a thermostable low-specificity L-threonine aldolase from Escherichia coli". European Journal of Biochemistry 255 (1): 220–6. July 1998. doi:10.1046/j.1432-1327.1998.2550220.x. PMID 9692922.
- ↑ "Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis". Molecular Systems Biology 6: 436. November 2010. doi:10.1038/msb.2010.88. PMID 21119630.
External links
- Low-specificity+L-threonine+aldolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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