Biology:Levopimaradiene synthase
From HandWiki
| Levopimaradiene synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.2.3.32 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming).[1][2] This enzyme catalyses the following chemical reaction
- (+)-copalyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] abieta-8(14),12-diene + diphosphate
In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.
References
- ↑ "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Archives of Biochemistry and Biophysics 392 (2): 263–9. August 2001. doi:10.1006/abbi.2001.2438. PMID 11488601.
- ↑ "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry 67 (15): 1572–8. August 2006. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
External links
- Levopimaradiene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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