Biology:Gluconate dehydratase

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Short description: Class of enzymes
gluconate dehydratase
Identifiers
EC number4.2.1.39
CAS number37290-75-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction

D-gluconate [math]\displaystyle{ \rightleftharpoons }[/math] 2-dehydro-3-deoxy-D-gluconate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in the pentose phosphate pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.

References

  • "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. 1969. doi:10.1007/BF00409760. PMID 5383859.