Biology:Indolepyruvate C-methyltransferase
| indolepyruvate C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.47 | ||||||||
| CAS number | 54576-88-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an indolepyruvate C-methyltransferase (EC 2.1.1.47) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + (indol-3-yl)pyruvate [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + (3S)-3-(indol-3-yl)-3-oxobutanoate
Thus, the two substrates of this enzyme are S-adenosyl methionine and (indol-3-yl)pyruvate, whereas its two products are S-adenosylhomocysteine and (3S)-3-(indol-3-yl)-3-oxobutanoate.
Nomenclature
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine: (indol-3-yl)pyruvate C-methyltransferase. Other names in common use include indolepyruvate methyltransferase, indolepyruvate 3-methyltransferase, indolepyruvic acid methyltransferase, and S-adenosyl-L-methionine:indolepyruvate C-methyltransferase. This enzyme participates in tryptophan metabolism.
References
- "Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus". Biochem. Biophys. Res. Commun. 39 (4): 594–9. May 1970. doi:10.1016/0006-291X(70)90245-7. PMID 5490210.
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