Biology:CAMK1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.

Further reading

• "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. 1992. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933. 
• "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains". J. Biol. Chem. 270 (40): 23851–9. 1995. doi:10.1074/jbc.270.40.23851. PMID 7559563. 
• "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. 268 (9): 6714–20. 1993. doi:10.1016/S0021-9258(18)53308-1. PMID 8384217. 
• "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I". J. Biol. Chem. 272 (50): 31235–40. 1998. doi:10.1074/jbc.272.50.31235. PMID 9395448. 
• "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. 1998. doi:10.1007/bf02258368. PMID 9662074. 
• "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. 1998. doi:10.1074/jbc.273.34.21473. PMID 9705275. 
• "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. 1998. doi:10.1074/jbc.273.48.31880. PMID 9822657. 
• "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. 1999. doi:10.1074/jbc.274.15.10086. PMID 10187789. 
• "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. 1999. doi:10.1074/jbc.274.29.20597. PMID 10400690. 
• "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron 24 (2): 377–87. 1999. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231. 
• "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. 2000. doi:10.1074/jbc.M003198200. PMID 10874031. 
• "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature 408 (6808): 106–11. 2000. doi:10.1038/35040593. PMID 11081517. Bibcode: 2000Natur.408..106M. 
• "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. 2001. doi:10.1073/pnas.260501497. PMID 11114197. Bibcode: 2000PNAS...9714400M. 
• "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. 2001. doi:10.1074/jbc.M011720200. PMID 11395482. 
• "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase". Endocrinology 143 (9): 3651–7. 2002. doi:10.1210/en.2001-211359. PMID 12193581. 
• "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin". J. Biol. Chem. 277 (47): 45473–9. 2003. doi:10.1074/jbc.M206673200. PMID 12237306. 
• "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry 41 (50): 14669–79. 2003. doi:10.1021/bi026660t. PMID 12475216. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. 2003. doi:10.1038/nm822. PMID 12539042. 

External links

• Human CAMK1 genome location and CAMK1 gene details page in the UCSC Genome Browser.